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C/EBP beta promotes the viability of human bladder cancer cell by. contributing to the transcription of bladder cancer specific lncRNA UCA1

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Clinical Laboratory, Peking University First Hospital, Beijing, 100034, China [2]Department of Central Laboratory, Peking University Shougang Hospital, Beijing, 100144, China [3]Department of Urology, Peking University First Hospital & Institute of Urology, Peking University, Beijing, 100034, China [4]Biobank for Clinical Data and Samples in Pediatric, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China [5]Department of Clinical Laboratory, Shandong Academy of Medical Sciences, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, 250117, Shandong, China

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关键词： UCA1 CiEBPB lncRNA Bladder cancer

摘要：

Urothelial Carcinoma Antigen 1 (UCA1) is a cell and tissue specific long non-coding RNA (lncRNA) associated with the tumorigenesis and invasion of bladder cancer. However, the mechanism driving the over-transcription of UCA1 in bladder cancer cells remains unclear. It has been reported that C/EBP beta has a significant role of regulation in tumorigenesis. Here we report that the expression of UCA1 was dramatically inhibited in 5637 cells with C/EBP beta down-regulation. Additionally, the function tests indicated that C/EBP beta could promote 5637 cells growth and colony formation by inducing the expression level of UCAl. These data suggest that C/EBP beta was involved in transcriptional regulation of UCA1 and contributed substantially to its high expression and proliferation promoting in bladder cancer cells. (C) 2018 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

JCR分区：

出版当年[2016]版：

Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.466 出版当年[2016版] 2.354 出版当年五年平均 2.371 出版前一年[2015版] 2.559 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Clinical Laboratory, Peking University First Hospital, Beijing, 100034, China

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通讯作者：

通讯机构： [3]Department of Urology, Peking University First Hospital & Institute of Urology, Peking University, Beijing, 100034, China [*1]Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, 7 Xi Shi Ku Street, Beijing, 100034, China

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