Primary intracranial germinoma is a rare intracranial lesion which accounts for approximately 0.5-2% of all intracranial tumors. Generally, primary intracranial germinoma occurs in the midline structures of the central nervous system of a pediatric patient. Only four cases of primary cerebellar germinomas with poor prognosis have been previously reported. The object of this paper is to introduce a case of germinoma originating from cerebellar hemisphere and to discuss its clinical features. This paper reported an 8-year-old boy who was diagnosed to have cerebella inflammatory granuloma during hospitalization and then discharged without any operation. However, the follow-up MRs revealed that the lesion became larger. Therefore, the boy was hospitalized again and underwent a gross total resection of lesion. According to pathological examination, the final diagnosis was confirmed as germinoma. Chemo- and radiotherapy were followed and so far, the patient showed good recovery without any recurrence and metastasis. Primary cerebellar germinoma has been rarely described in previous literatures. In this paper, a primary cerebellar germinoma was reported and its clinical features and treatments were discussed. The tumor's significant shrinkage by CT- scan was firstly reported and maybe this would provide a valuable hint for the diagnosis and treatment on the intracranial germinomas in children.
基金:
National Natural Science Funding, Beijing [31271119]; high-level technical talents cultivation plan in the Beijing Municipal Planning Commission Funding [2013-3-045]
第一作者机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Pediat Neurosurg, Beijing 100050, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Pediat Neurosurg, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714):
Wang Lei,Zhu Wanchun,Li Xiang,et al.A rare case report and literatures review on primary germinoma in cerebellar hemisphere[J].CHILDS NERVOUS SYSTEM.2017,33(11):2039-2045.doi:10.1007/s00381-017-3502-2.
APA:
Wang, Lei,Zhu, Wanchun,Li, Xiang,He, Jintao,Li, Chunde&Gong, Jian.(2017).A rare case report and literatures review on primary germinoma in cerebellar hemisphere.CHILDS NERVOUS SYSTEM,33,(11)
MLA:
Wang, Lei,et al."A rare case report and literatures review on primary germinoma in cerebellar hemisphere".CHILDS NERVOUS SYSTEM 33..11(2017):2039-2045