Retinol dehydrogenase-10 (RDH10) is a member of the short-chain dehydrogenase/reductase family, which plays an important role in retinoic acid (RA) synthesis. Here, we show that RDH10 is highly expressed in human gliomas, and its expression correlates with tumor grade and patient survival times. In vitro, lentivirus-mediated shRNA knockdown of RDH10 suppressed glioma cell proliferation, survival, and invasiveness and cell cycle progression. In vivo, RDH10 knockdown reduced glioma growth in nude mice. Microarray analysis revealed that RDH10 silencing reduces expression of TNFRSF12A (Fn14), TNFSF12 (TWEAK), TRAF3, IKBKB (IKK-beta), and BMPR2, while it increases expression of TRAF1, NFKBIA (I kappa B alpha), NFKBIE (I kappa B epsilon), and TNFAIP3. This suggests that RDH10 promotes glioma cell proliferation and survival by regulating the TWEAK-NF-kappa B axis, and that it could potentially serve as a novel target for human glioma treatment.
基金：
Research Special Fund for Public Welfare Industry of Health of China [201402008]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Guan Feng,Wang Liang,Hao Shuyu,et al.Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-kappa B axis[J].ONCOTARGET.2017,8(62):105262-105275.doi:10.18632/oncotarget.22166.
APA：
Guan, Feng,Wang, Liang,Hao, Shuyu,Wu, Zhen,Bai, Jian...&Zhang, Junting.(2017).Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-kappa B axis.ONCOTARGET,8,(62)
MLA：
Guan, Feng,et al."Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-kappa B axis".ONCOTARGET 8..62(2017):105262-105275
医学