External Validation of the Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale Score for Predicting Pneumonia After Stroke Using Data From the China National Stroke Registry
Background and purpose: Pneumonia is an important risk factor for mortality and morbidity after stroke. The Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN) score was shown to be a useful tool for predicting stroke-associated pneumonia based on UK multicenter cohort study. We aimed to externally validate the score using data from the China National Stroke Registry (CNSR). Methods: Eligible patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) in the CNSR from 2007 to 2008 were included. The area under the receiver operating characteristic (AUC) curve was used to evaluate discrimination. The Hosmer-Lemeshow goodness of fit test and Pearson correlation coefficient were performed to assess calibration of the model. Results: A total of 19,333 patients (AIS = 14400; ICH = 4933) were included and the overall pneumonia rate was 12.7%. The AUC was.76 (95% confidence interval [ CI]:.75-.78) for the subgroup of AIS and.70 (95% CI:.68-. 72) for the subgroup of ICH. The Hosmer-Lemeshow test showed the ISAN score with the good calibration for AIS and ICH (P = .177 and .405, respectively). The plot of observed versus predicted pneumonia rates suggested higher correlation for patients with AIS than with ICH (Pearson correlation coefficient = .99 and .83, respectively). Conclusions: The ISAN score was a useful tool for predicting in-hospital pneumonia after acute stroke, especially for patients with AIS. Further validations need to be done in different populations.
基金：
Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [D131100002313002]; Beijing Municipal Commission of Health and Family Planning [2016-1-2041]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471208]; Beijing high-level healthy human resource project [2014-3-033]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 6 Tiantanxili, Beijing 100050, Peoples R China;[2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China;[3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China;[4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Runhua,Ji Ruijun,Pan Yuesong,et al.External Validation of the Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale Score for Predicting Pneumonia After Stroke Using Data From the China National Stroke Registry[J].JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2017,26(5):938-943.doi:10.1016/j.jstrokecerebrovasdis.2016.10.043.
APA：
Zhang, Runhua,Ji, Ruijun,Pan, Yuesong,Jiang, Yong,Liu, Gaifen...&Wang, Yongjun.(2017).External Validation of the Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale Score for Predicting Pneumonia After Stroke Using Data From the China National Stroke Registry.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,26,(5)
MLA：
Zhang, Runhua,et al."External Validation of the Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale Score for Predicting Pneumonia After Stroke Using Data From the China National Stroke Registry".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26..5(2017):938-943
