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RhoGDI alpha suppresses self-renewal and tumorigenesis of glioma stem cells

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收录情况： ◇ SCIE

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机构： [1]Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Med Mol Biol, Dept Mol Biol & Biochem,Inst Med Sci,Sch Basic Me, Beijing 100005, Peoples R China; [2]Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China

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关键词： GSCs RhoGDI alpha self-renewal ROCK1 Oct4

摘要：

Glioma stem cells (GSCs) are a subset of tumor cells that drive glioma initiation and progression. The molecular mechanisms underlying the maintenance of GSCs are still poorly understood. Here we investigated the role of Rho GDP dissociation inhibitor a (RhoGDI alpha) in GSCs. RhoGDI alpha was down-regulated in glioma stem cells. Over-expression of RhoGDI alpha suppressed the self-renewal and tumorigenesis of GSCs. Further data showed that RhoGDI alpha inhibited the transcription activity of stem cell marker Oct4. Moreover, inactivation of ROCK1, a downstream effector of RhoGDI alpha, also decreased the self-renewal and Oct4 transcription activity, and rescued the effects caused by RhoGDI alpha knockdown. Our results indicate that RhoGDI alpha is involved in the maintenance of GSCs.

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出版当年[2015]版：

大类 | 1 区

医学

小类 | 2 区肿瘤学 3 区细胞生物学

最新[2023]版：

无

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出版当年[2014]版：

Q1 ONCOLOGY Q1 CELL BIOLOGY

最新[2023]版：

无

影响因子： 0 最新[2023版] 0 最新五年平均 6.359 出版当年[2014版] 6.368 出版当年五年平均 6.627 出版前一年[2013版] 5.008 出版后一年[2015版]

第一作者：

第一作者机构： [1]Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Med Mol Biol, Dept Mol Biol & Biochem,Inst Med Sci,Sch Basic Me, Beijing 100005, Peoples R China;

通讯作者：

通讯机构： [1]Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Med Mol Biol, Dept Mol Biol & Biochem,Inst Med Sci,Sch Basic Me, Beijing 100005, Peoples R China;

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