Kindlin-2 promotes carcinogenesis through regulation of cell-cell and cell-extracellular matrix adhesion. However, the role of Kindlin-2 in glioma has not been elucidated. We investigated Kindlin-2 expression in 188 human glioma tissue samples. High Kindlin-2 expression was correlated with high pathological grade and a worse prognosis. Kindlin-2 promoted glioma cell motility and proliferation both in vitro and in vivo. Importantly, Kindlin-2 activated the EGFR pathway and increased EGFR mRNA levels. In addition to up-regulating Y-box binding protein-1 (YB-1) and beta-catenin expression, Kindlin-2 formed a transcriptional complex with YB-1 and beta-catenin that bound to the EGFR promoter and enhanced transcription. The beta-catenin/YB-1/EGFR pathway was required for Kindlin-2-mediated functions. Our data provide a better understanding of the mechanisms underlying glioma progression, and suggest that Kindlin-2 may be a biomarker and therapeutic target in glioma.
基金：
National 973 ProgramNational Basic Research Program of China [2015CB553904]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81230047, 8132109, 81502150, 81472661]; Young Foundation of Beijing Tiantan Hospital of Capital Medical University [2014-YQN-YS-02]; Beijing Outstanding Talent Training Project [2015000021469G222]; National Basic Research Program of ChinaNational Basic Research Program of China [2012CB967003]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2014BAI04B01, 2015BAI12B04, 2013BAI09B03]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AR064874, AR068950]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[2]Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China;[3]Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China;[4]Peking Union Med Coll, Beijing 100021, Peoples R China;[5]Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China;[6]Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China;[10]China Natl Clin Res Ctr Neurol Dis, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[2]Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China;[3]Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China;[4]Peking Union Med Coll, Beijing 100021, Peoples R China;[6]Capital Med Univ, Beijing Sanbo Brain Hosp, Dept Neurosurg, Beijing 100093, Peoples R China;
推荐引用方式(GB/T 7714)：
Ou Yunwei,Zhao Zitong,Zhang Weimin,et al.Kindlin-2 interacts with beta-catenin and YB-1 to enhance EGFR transcription during glioma progression[J].ONCOTARGET.2016,7(46):74872-74885.doi:10.18632/oncotarget.12439.
APA：
Ou, Yunwei,Zhao, Zitong,Zhang, Weimin,Wu, Qingnan,Wu, Chuanyue...&Zhan, Qimin.(2016).Kindlin-2 interacts with beta-catenin and YB-1 to enhance EGFR transcription during glioma progression.ONCOTARGET,7,(46)
MLA：
Ou, Yunwei,et al."Kindlin-2 interacts with beta-catenin and YB-1 to enhance EGFR transcription during glioma progression".ONCOTARGET 7..46(2016):74872-74885
医学