Hematopoietic stem cell transplantation (HSCT) is a promising method for therapy of pediatric patients with acute leukemia. However, less availability of matched donors limited its wide application. Recently, haploidentical HSCT has become a great resource. Here, we have retrospectively reported our experience of 20 pediatric patients with acute leukemia who underwent haploidentical HSCT without total body irradiation (TBI) myeloablative regimen in our center from November 2007 to June 2014. All the patients attained successful HSCT engraftment in terms of myeloid and platelet recovery. Thirteen patients developed grade I-IV acute graft-versus-host disease (a-GVHD). The incidence of grade I-II a-GVHD, grade III-IV a-GVHD, and chronic GVHD (c-GVHD) was 45%, 20%, and 25%, respectively. The mean myeloid and platelet recovery time was 13.20 +/- 2.41 and 19.10 +/- 8.37 days. The median follow-up time was 43.95 +/- 29.26 months. During the follow-up, three patients died. The overall survival (OS) rate was 85%. The present study indicated that haploidentical HSCT without TBI myeloablative regimen significantly improved the OS rate of pediatric patients with acute leukemia.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81300433]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7144211]; Specialized Research Fund for the Doctoral Program of Higher EducationSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20131107120008]; BCH Young Investigator Program [BCHYIPA-2013-06]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZY201404]
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Minist Educ,Beijing Key Lab Pediat Hematol Oncol, Key Lab Major Dis Children,Hematol Oncol Ctr,Natl, Beijing 100045, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Minist Educ,Beijing Key Lab Pediat Hematol Oncol, Key Lab Major Dis Children,Hematol Oncol Ctr,Natl, Beijing 100045, Peoples R China;[2]Capital Med Univ, Beijing Childrens Hosp, Hematol Oncol Ctr, 56 Nanlishi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Mu Yanshun,Qin Maoquan,Wang Bin,et al.Haploidentical hematopoietic stem cell transplantation without total body irradiation for pediatric acute leukemia: a single-center experience[J].ONCOTARGETS AND THERAPY.2016,9:2557-2563.doi:10.2147/OTT.S102286.
APA：
Mu, Yanshun,Qin, Maoquan,Wang, Bin,Li, Sidan,Zhu, Guanghua...&Zheng, Huyong.(2016).Haploidentical hematopoietic stem cell transplantation without total body irradiation for pediatric acute leukemia: a single-center experience.ONCOTARGETS AND THERAPY,9,
MLA：
Mu, Yanshun,et al."Haploidentical hematopoietic stem cell transplantation without total body irradiation for pediatric acute leukemia: a single-center experience".ONCOTARGETS AND THERAPY 9.(2016):2557-2563
