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HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-beta pathways

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收录情况： ◇ SCIE

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机构： [1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurosurg, Beijing, Peoples R China; [2]Tianjin Neurol Inst, Lab Neurooncol, Tianjin, Peoples R China; [3]Tianjin Med Univ, Gen Hosp, Dept Neurosurg, Tianjin, Peoples R China; [4]Minist Educ & Tianjin Municipal Govt, Key Lab Neurotrauma Variat & Regenerat, Tianjin, Peoples R China; [5]CGCG, Beijing, Peoples R China; [6]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China

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关键词： Homeobox (HOX) gene HOXA13 glioma smad epithelial-to-mesenchymal transition (EMT)

摘要：

Homeobox ( HOX) genes, including HOXA13, are involved in human cancer. We found that HOXA13 expression was associated with glioma grade and prognosis. Bioinformatics analysis revealed that most of the HOXA13-associated genes were enriched in cancer-related signaling pathways and mainly involved in the regulation of transcription. We transfected four glioma cell lines with Lenti-si HOXA13. HOXA13 increased cell proliferation and invasion and inhibited apoptosis. HOXA13 decreased beta-catenin, phospho-smad2, and phospho-smad3 in the nucleus and increased phospho-beta-catenin in the cytoplasm. Furthermore, downregulation of HOXA13 in orthotopic tumors decreased tumor growth. We suggest that HOXA13 promotes glioma progression in part via Wnt- and TGF-beta-induced EMT and is a potential diagnostic biomarker for glioblastoma and an independent prognostic factor in high-grade glioma.

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出版当年[2014]版：

大类 | 2 区医学

小类 | 2 区肿瘤学 3 区细胞生物学

最新[2025]版：

无

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出版当年[2013]版：

Q1 ONCOLOGY Q1 CELL BIOLOGY

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无

影响因子： 0 最新[2023版] 0 最新五年平均 6.627 出版当年[2013版] 6.402 出版当年五年平均 6.636 出版前一年[2012版] 6.359 出版后一年[2014版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurosurg, Beijing, Peoples R China; [5]CGCG, Beijing, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Tian Tan Hosp, Dept Neurosurg, Beijing, Peoples R China; [5]CGCG, Beijing, Peoples R China; [6]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China

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