机构：[1]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China临床科室急诊危重症中心首都医科大学附属安贞医院[2]Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China[3]Department of Pulmonary and Critical Care Medicine, Peking University International Hospital, Beijing, China[4]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China临床科室心脏内科中心首都医科大学附属安贞医院
Vascular calcification is extremely common and associated with major adverse cardiovascular events. Fibroblast growth factor (FGF) 21 has been identified as a potent metabolic regulator and a protector of the cardiovascular system. In this study, we aimed to investigate the effect of FGF21 on calcification of vascular smooth muscle cell (VSMC) and its mechanism. FGF21 inhibited beta-glycerophosphate (BGP) induced mineralization in VSMCs as determined by calcium concentration and Alizarin Red S. FGF21 suppressed BGP-induced BMP2/Smad signaling pathway components as well as osteoblast differentiation markers. FGF21 and Noggin could synergistically inhibit BGP-induced BMP2/Smad pathway expressions and calcification. Taken together, FGF21 inhibits vascular calcification in vitro by modulating BMP2/Smad signaling pathway. (C) 2018 Published by Elsevier Inc.
基金：
National Natural Science Fund of ChinaNational Natural Science Foundation of China [81570388]
第一作者机构：[1]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
通讯作者：
通讯机构：[4]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China
推荐引用方式(GB/T 7714)：
Liu Xiaoxiao,Cao Fangying,Liu Shuang,et al.BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,503(2):930-937.doi:10.1016/j.bbrc.2018.06.098.
APA：
Liu, Xiaoxiao,Cao, Fangying,Liu, Shuang,Mi, Yuhong&Liu, Jinghua.(2018).BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503,(2)
MLA：
Liu, Xiaoxiao,et al."BMP2/Smad signaling pathway is involved in the inhibition function of fibroblast growth factor 21 on vascular calcification".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503..2(2018):930-937
