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High expression of CXCR3 is an independent prognostic factor in glioblastoma patients that promotes an invasive phenotype

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收录情况： ◇ SCIE

作者：

机构： [1]Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Dept Neurosurg, Wuxi, Peoples R China; [2]Capital Med Univ, Beijing San Bo Brain Hosp, Dept Neurosurg, Beijing, Peoples R China; [3]Beijing Tiantan Hosp, Capital Med Univ, Dept Neurosurg, Beijing, Peoples R China

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关键词： Glioblastoma CXCR3 Prognostic Invasion

摘要：

Chemokines are a superfamily of small heparin-binding cytokines that induce leukocytes to migrate to sites of inflammation or injury through interacting with specific transmembrane G protein-coupled receptors. Currently, attention is focused on chemokine/chemokine receptor pairs and their ability to promote tumor cell migration and angiogenesis. The chemokine receptor CXCR3 is involved in tumor metastasis and is used as a prognostic biomarker. However, its relationship with the clinicopathological features of primary glioblastoma multiforme (pGBM) and its potential prognostic value have yet to be investigated. Here, we report that high CXCR3 expression conferred poor survival in pGBM patients. Further analysis showed that CXCR3 served as an independent prognostic biomarker for pGBM patients. In addition, functional assays indicated that CXCR3 induced glioma cell invasion. Therefore, this evidence indicates CXCR3 is an independent prognostic factor for pGBM patients and promotes an invasive phenotype, which suggests a new potential biotarget for glioblastoma multiforme therapy.

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出版当年[2014]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区临床神经病学 3 区肿瘤学

JCR分区：

出版当年[2013]版：

Q2 ONCOLOGY Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q2 CLINICAL NEUROLOGY Q2 ONCOLOGY

影响因子： 3.2 最新[2023版] 3.7 最新五年平均 2.787 出版当年[2013版] 2.95 出版当年五年平均 3.115 出版前一年[2012版] 3.07 出版后一年[2014版]

第一作者：

第一作者机构： [1]Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Dept Neurosurg, Wuxi, Peoples R China;

通讯作者：

通讯机构： [1]Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Dept Neurosurg, Wuxi, Peoples R China;

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