PTPRZ1-MET (ZM) proteins are a group of fusion proteins identified in human gliomas by high-throughput transcriptome sequencing. ZM fusions are associated with poor prognosis in afflicted glioma patients and mediate oncogenic effects in assays. In this study, we show that ZM-carrying patients have increased hepatocyte growth factor receptor (MET) mRNA expression levels induced by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1). Furthermore, ZM fusions preserve fundamental properties of wild-type MET with respect to processing and dimerization, and enhance phosphorylation in an hepatocyte growth factor (HGF)-dependent and independent manner. Our findings suggest that ZM induces gliomas through elevated expression and phosphorylation of the MET oncoprotein. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
基金：
biological medicine department, Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z141100000214009]; National High Technology Research and Development ProgramNational High Technology Research and Development Program of China [2012AA02A508]; International Science and Technology Cooperation Program [2012DFA30470]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [91229121]
第一作者机构：[1]Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China;[2]Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen, Peoples R China;
通讯作者：
通讯机构：[1]Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China;
推荐引用方式(GB/T 7714)：
Chen Hui-Min,Yu Kai,Tang Xiao-yan,et al.Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions[J].FEBS LETTERS.2015,589(13):1437-1443.doi:10.1016/j.febslet.2015.04.032.
APA：
Chen, Hui-Min,Yu, Kai,Tang, Xiao-yan,Bao, Zhao-shi,Jiang, Tao...&Su, Xiao-Dong.(2015).Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions.FEBS LETTERS,589,(13)
MLA：
Chen, Hui-Min,et al."Enhanced expression and phosphorylation of the MET oncoprotein by glioma-specific PTPRZ1-MET fusions".FEBS LETTERS 589..13(2015):1437-1443
