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The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system

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收录情况： ◇ 统计源期刊 ◇ CSCD-C

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机构： [a]Department of Neonatology and NICU of Bayi Children’s Hospital, General Hospital of Beijing Military Command of Chinese PLA, Beijing, China [b]Department of Neonatology, People’s Hospital of Rizhao, Rizhao, Shangdong Province, China

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关键词： Axonal regeneration Central nervous system Microenvironment Nerve regeneration Neural regeneration NSFC grant Reviews Rho/Rho-associated coiled-coil containing protein kinase Signaling pathway

摘要：

The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore, a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system. © 2015, Editorial Board of Neural Regeneration Research. All rights reserved.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区神经科学

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