rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children
机构：[1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, Beijing 100045, Peoples R China;科研平台儿科研究所首都医科大学附属北京儿童医院[2]Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, 56 Nan Li Shi Rd, Beijing 100045, Peoples R China科研平台儿科研究所首都医科大学附属北京儿童医院
Interleukin-4 (IL-4) and IL-10, which are produced by Th2 cells, serve as anti-inflammatory cytokines in the immune responses to tuberculosis (TB). In order to investigate the association between susceptibility to TB and single-nucleotide polymorphisms (SNPs) of the IL-4 and IL-10 genes, a case-control study including 346 TB patients and 374 healthy controls was performed in Chinese Han children in North China. Though no significant differences in the allelic and genotypic distributions of SNPs of these two genes were observed between control group and TB group, rs2243268-A and rs2243274-G of the IL-4 gene were associated with reduced risk of developing extrapulmonary tuberculosis (EPTB) (P-rs2243268 = 0.005 and P-rs2243274 = 0.004) and severe TB (P-rs2243268 = 0.003 and Prs2243274 = 0.003). The haplotype comprising rs2243268-A and rs2243274-G was found to be a resistance factor against EPTB and severe TB. In addition, after stimulation with inactivated H37Rv, blood samples of the rs2243268 AA + AC carriers showed significantly reduced IL-10 production (P = 0.045) compared to the CC carriers. In conclusion, rs2243268-A and rs2243274-G of the IL-4 gene were found to confer resistance to EPTB and severe TB in Chinese Han children. (C) 2014 Elsevier B.V. All rights reserved.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7121007]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30901632]; Beijing Post-doctoral Research Foundation; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, Beijing 100045, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, Beijing 100045, Peoples R China;[3]Capital Med Univ, Beijing Childrens Hosp, Key Lab Major Dis Children & Natl Key Discipline, Minist Educ,Beijing Pediat Res Inst, 56 Nan Li Shi Rd, Beijing 100045, Peoples R China
推荐引用方式(GB/T 7714)：
Qi Hui,Sun Lin,Jin Ya-Qiong,et al.rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children[J].INFECTION GENETICS AND EVOLUTION.2014,23:121-128.doi:10.1016/j.meegid.2014.01.031.
APA：
Qi, Hui,Sun, Lin,Jin, Ya-Qiong,Shen, Chen,Chu, Ping...&Shen, A-Dong.(2014).rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children.INFECTION GENETICS AND EVOLUTION,23,
MLA：
Qi, Hui,et al."rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children".INFECTION GENETICS AND EVOLUTION 23.(2014):121-128
