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Procalcitonin for the differential diagnosis of infectious and non-infectious systemic inflammatory response syndrome after cardiac surgery

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机构： [1]Capital Med Univ, Beijing Tongren Hosp, Dept Crit Care Med, Beijing 100730, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Dept Crit Care Med, Beijing 100050, Peoples R China; [3]Tokyo Med & Dent Univ, Grad Sch, Dept Crit Care Med, Tokyo 1138519, Japan; [4]Tokyo Med & Dent Univ, Grad Sch, Dept Cardiovasc Surg, Tokyo 1138519, Japan

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关键词： Procalcitonin Systemic inflammatory response syndrome Cardiac surgery Infection C-reactive protein

摘要：

Background: This study was performed to assess the value of procalcitonin (PCT) for the differential diagnosis between infectious and non-infectious systemic inflammatory response syndrome (SIRS) after cardiac surgery. Methods: Patients diagnosed with SIRS after cardiac surgery between April 1, 2011 and March 31, 2013 were retrospectively studied. A total of 142 patients with SIRS, infectious (n = 47) or non-infectious (n = 95), were included. The patients with infectious SIRS included 11 with sepsis, 12 with severe sepsis without shock, and 24 with septic shock. Results: PCT, C-reactive protein (CRP), and the white blood cell (WBC) count were significantly higher in the infectious SIRS group than in the non-infectious SIRS group. PCT had the highest sensitivity and specificity for differential diagnosis, with a cut-off value for infectious SIRS of 0.47 ng/mL. PCT was more reliable than CRP in diagnosing severe sepsis without shock, but it was not useful for diagnosing septic shock. The PCT cut-off value for diagnosing severe sepsis without shock was 2.28 ng/mL. Conclusions: PCT was a useful marker for the diagnosis of infectious SIRS after cardiac surgery. The optimal PCT cut-off value for diagnosing infectious SIRS was 0.47 ng/mL.

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大类 | 2 区医学

小类 | 3 区危重病医学

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tongren Hosp, Dept Crit Care Med, Beijing 100730, Peoples R China; [3]Tokyo Med & Dent Univ, Grad Sch, Dept Crit Care Med, Tokyo 1138519, Japan;

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通讯机构： [3]Tokyo Med & Dent Univ, Grad Sch, Dept Crit Care Med, Tokyo 1138519, Japan;

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