机构：[1]Chinese Acad Med Sci, State Key Lab Med Mol Biol, Dept Mol Biol & Biochem, Inst Basic Med Sci, Beijing 100005, Peoples R China;[2]Peking Union Med Coll, Beijing 100005, Peoples R China;[3]Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院
Although the roles of circadian Clock genes and microRNAs in tumorigenesis have been profoundly studied, mechanisms of cross-talk between them in regulation of gliomagenesis are poorly understood. Here we show that the expression level of CLOCK is significantly increased in high-grade human glioma tissues and glioblastoma cell lines. In contrast miR-124 is attenuated in similar samples. Further studies show that Clock is a direct target of miR-124, and either restoration of miR-124 or silencing of CLOCK can reduce the activation of NF-kappa B. In conclusion, we suggest that as a target of glioma suppressor miR-124, CLOCK positively regulates glioma proliferation and migration by reinforcing NF-kappa B activity. (C) 2013 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
基金：
National Basic Research Program of ChinaNational Basic Research Program of China [2011CBA01104, 2007CB946902, 2009CB825403, 2013CB531304]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30825023, 31071203]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-07-0505]; 111 ProjectMinistry of Education, China - 111 Project [B08007]
第一作者机构：[1]Chinese Acad Med Sci, State Key Lab Med Mol Biol, Dept Mol Biol & Biochem, Inst Basic Med Sci, Beijing 100005, Peoples R China;[2]Peking Union Med Coll, Beijing 100005, Peoples R China;
通讯作者：
通讯机构：[1]Chinese Acad Med Sci, State Key Lab Med Mol Biol, Dept Mol Biol & Biochem, Inst Basic Med Sci, Beijing 100005, Peoples R China;[2]Peking Union Med Coll, Beijing 100005, Peoples R China;
推荐引用方式(GB/T 7714)：
Li Aihua,Lin Xihua,Tan Xiaochao,et al.Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124[J].FEBS LETTERS.2013,587(15):2455-2460.doi:10.1016/j.febslet.2013.06.018.
APA：
Li, Aihua,Lin, Xihua,Tan, Xiaochao,Yin, Bin,Han, Wei...&Peng, Xiaozhong.(2013).Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124.FEBS LETTERS,587,(15)
MLA：
Li, Aihua,et al."Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124".FEBS LETTERS 587..15(2013):2455-2460
