Gestational trophoblastic diseases include hydatidiform moles, invasive moles, choriocarcinoma, placental-site trophoblastic tumours and miscellaneous trophoblastic lesions. Choriocarcinoma is a rare disease that arises from the trophoblastic epithelium of the placenta at the beginning of pregnancy. Among the confirmed cases, 45% occur after molar pregnancy, 25% after normal pregnancy, 25% after an abortion and 5% after ectopic pregnancy. This tumour is usually diagnosed based on its histopathologic appearance and a high level of serum beta-human chorionic gonadotropin (beta-HCG). Choriocarcinoma exhibits a good response to chemotherapy and radiation. However, it is also known for its tendency to spread rapidly to multiple organs, including the lungs, liver and brain. As one of the worst prognostic factors, brain metastasis complicates 3-28% of gestational choriocarcinoma cases. Increased beta-HCG levels and a low serum cerebrospinal fluid beta-HCG level can be strongly suggestive of intracranial choriocarcinoma, even in the absence of histopathologically proven disease. Reviewing the literature, there were 23 cases of intracerebral haemorrhage from an oncotic aneurysm as an initial presentation of choriocarcinoma. We report a further case of intracerebral haematoma secondary to oncotic aneurysm as the first presentation of metastatic choriocarcinoma with normal serum beta-HCG. (C) 2013 Elsevier Ltd. All rights reserved.
第一作者机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 6 Tiantan Xili, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714):
Wang Jia,Wang Rong,Zhao Jizong.Ruptured cerebral aneurysm from choriocarcinoma[J].JOURNAL OF CLINICAL NEUROSCIENCE.2013,20(9):1324-1326.doi:10.1016/j.jocn.2012.09.045.
APA:
Wang, Jia,Wang, Rong&Zhao, Jizong.(2013).Ruptured cerebral aneurysm from choriocarcinoma.JOURNAL OF CLINICAL NEUROSCIENCE,20,(9)
MLA:
Wang, Jia,et al."Ruptured cerebral aneurysm from choriocarcinoma".JOURNAL OF CLINICAL NEUROSCIENCE 20..9(2013):1324-1326