A flow diverter (FD) is a flexible, densely braided stent-mesh device placed endoluminally across an intracranial aneurysm to induce its thrombotic occlusion. FD treatment planning using computational virtual stenting and flow simulation requires accurate representation of the expanded FD geometry. We have recently developed a high fidelity virtual stenting (HiFiVS) technique based on finite element analysis to simulate detailed FD deployment processes in patient-specific aneurysms (Ma et al. J. Biomech. 45:2256-2263, 2012). This study tests if HiFiVS simulation can recapitulate real-life FD implantation. We deployed two identical FDs (Pipeline Embolization Device) into phantoms of a wide-necked segmental aneurysm using a clinical push-pull technique with different delivery wire advancements. We then simulated these deployment processes using HiFiVS and compared results against experimental recording. Stepwise comparison shows that the simulations precisely reproduced the FD deployment processes recorded in vitro. The local metal coverage rate and pore density quantifications demonstrated that simulations reproduced detailed FD mesh geometry. These results provide validation of the HiFiVS technique, highlighting its unique capability of accurately representing stent intervention in silico.
基金:
NIH/NINDSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01NS064592]; Toshiba Medical Systems, Covidien [VTGCC053012-009]; National Science Foundation of ChinaNational Natural Science Foundation of China [81220108007, 81171079]
第一作者机构:[1]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, Buffalo, NY 14203 USA;[2]SUNY Buffalo, Dept Mech & Aerosp Engn, Buffalo, NY 14203 USA;
通讯作者:
通讯机构:[1]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, Buffalo, NY 14203 USA;[2]SUNY Buffalo, Dept Mech & Aerosp Engn, Buffalo, NY 14203 USA;[3]SUNY Buffalo, Dept Neurosurg, Buffalo, NY 14203 USA;[5]SUNY Buffalo, Dept Biomed Engn, Buffalo, NY 14203 USA;[8]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, 875 Ellicott St, Buffalo, NY 14203 USA
推荐引用方式(GB/T 7714):
Ma Ding,Dumont Travis M.,Kosukegawa Hiroyuki,et al.High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico[J].ANNALS OF BIOMEDICAL ENGINEERING.2013,41(10):2143-2156.doi:10.1007/s10439-013-0808-4.
APA:
Ma, Ding,Dumont, Travis M.,Kosukegawa, Hiroyuki,Ohta, Makoto,Yang, Xinjian...&Meng, Hui.(2013).High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico.ANNALS OF BIOMEDICAL ENGINEERING,41,(10)
MLA:
Ma, Ding,et al."High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico".ANNALS OF BIOMEDICAL ENGINEERING 41..10(2013):2143-2156