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High Fidelity Virtual Stenting (HiFiVS) for Intracranial Aneurysm Flow Diversion: In Vitro and In Silico

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收录情况: ◇ SCIE

机构: [1]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, Buffalo, NY 14203 USA; [2]SUNY Buffalo, Dept Mech & Aerosp Engn, Buffalo, NY 14203 USA; [3]SUNY Buffalo, Dept Neurosurg, Buffalo, NY 14203 USA; [4]SUNY Buffalo, Dept Radiol, Buffalo, NY 14203 USA; [5]SUNY Buffalo, Dept Biomed Engn, Buffalo, NY 14203 USA; [6]Tohoku Univ, Inst Fluid Sci, Sendai, Miyagi 980, Japan; [7]Capital Med Univ, Beijing Tiantan Hosp, Beijing Neurosurg Inst, Beijing, Peoples R China; [8]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, 875 Ellicott St, Buffalo, NY 14203 USA
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关键词: Flow diverter Pipeline Embolization Device Stent deployment Intracranial aneurysm Finite element analysis Braided stent

摘要:
A flow diverter (FD) is a flexible, densely braided stent-mesh device placed endoluminally across an intracranial aneurysm to induce its thrombotic occlusion. FD treatment planning using computational virtual stenting and flow simulation requires accurate representation of the expanded FD geometry. We have recently developed a high fidelity virtual stenting (HiFiVS) technique based on finite element analysis to simulate detailed FD deployment processes in patient-specific aneurysms (Ma et al. J. Biomech. 45:2256-2263, 2012). This study tests if HiFiVS simulation can recapitulate real-life FD implantation. We deployed two identical FDs (Pipeline Embolization Device) into phantoms of a wide-necked segmental aneurysm using a clinical push-pull technique with different delivery wire advancements. We then simulated these deployment processes using HiFiVS and compared results against experimental recording. Stepwise comparison shows that the simulations precisely reproduced the FD deployment processes recorded in vitro. The local metal coverage rate and pore density quantifications demonstrated that simulations reproduced detailed FD mesh geometry. These results provide validation of the HiFiVS technique, highlighting its unique capability of accurately representing stent intervention in silico.

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出版当年[2012]版:
大类 | 2 区 工程技术
小类 | 3 区 工程:生物医学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 工程:生物医学
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出版当年[2011]版:
Q2 ENGINEERING, BIOMEDICAL
最新[2023]版:
Q3 ENGINEERING, BIOMEDICAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2011版] 出版当年五年平均 出版前一年[2010版] 出版后一年[2012版]

第一作者:
第一作者机构: [1]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, Buffalo, NY 14203 USA; [2]SUNY Buffalo, Dept Mech & Aerosp Engn, Buffalo, NY 14203 USA;
通讯作者:
通讯机构: [1]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, Buffalo, NY 14203 USA; [2]SUNY Buffalo, Dept Mech & Aerosp Engn, Buffalo, NY 14203 USA; [3]SUNY Buffalo, Dept Neurosurg, Buffalo, NY 14203 USA; [5]SUNY Buffalo, Dept Biomed Engn, Buffalo, NY 14203 USA; [8]SUNY Buffalo, Toshiba Stroke & Vasc Res Ctr, 875 Ellicott St, Buffalo, NY 14203 USA
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