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Evaluation of a method for the simultaneous detection of multiple tumor markers using a multiplex suspension bead array

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收录情况： ◇ SCIE

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机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Lab Diag, Beijing 100050, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Lab Clin Med Res, Beijing 100050, Peoples R China; [3]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China; [4]Capital Med Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100069, Peoples R China; [5]Shanghai Tellgen Life Sci Co Ltd, Shanghai 201203, Peoples R China; [6]Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Lab Diag, 6 Tiantan Xili, Beijing 100050, Peoples R China

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关键词： Multiplex suspension bead array Tumor marker

摘要：

Objective: To achieve higher tumor detection efficiency, we evaluated a multiplex assay for TM analysis based on the Luminex-100 multiplex suspension bead array. Design: The assay simultaneously determined the concentrations of nine TMs in 1114 human serum specimens (546 patients with tumors, 158 patients with non-tumor inflammatory diseases, and 410 normal controls). The nine TMs were AFP, CEA, CA125, CYFRA 21-1, CA242, f-PSA, t-PSA, NSE and free beta-hCG. The multiplex suspension bead assays were compared with conventional methods used in clinical laboratories. Results: The Luminex assay has the same levels of sensitivity, specificity and accuracy in the prediction of positive tumor specimens as conventional methods. Conclusion: Multiplex suspension bead arrays have promising applications in clinical laboratories. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2011]版：

大类 | 4 区医学

小类 | 3 区医学实验技术

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学实验技术

JCR分区：

出版当年[2010]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

最新[2023]版：

Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 2.5 最新[2023版] 3.2 最新五年平均 2.043 出版当年[2010版] 2.238 出版当年五年平均 2.019 出版前一年[2009版] 2.076 出版后一年[2011版]

第一作者：

第一作者机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Lab Diag, Beijing 100050, Peoples R China; [2]Capital Med Univ, Beijing Tiantan Hosp, Lab Clin Med Res, Beijing 100050, Peoples R China; [3]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China;

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Lab Diag, Beijing 100050, Peoples R China; [6]Capital Med Univ, Beijing Tiantan Hosp, Dept Clin Lab Diag, 6 Tiantan Xili, Beijing 100050, Peoples R China

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