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Tumor necrosis factor alpha 308 G/A polymorphism and Guillain-Barre syndrome risk

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收录情况： ◇ SCIE

作者：

机构： [1]Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China; [2]Capital Med Univ, Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China; [3]Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, 246 Xuefu Rd, Harbin 150086, Heilongjiang, Peoples R China

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关键词： Guillain-Barre syndrome Tumor necrosis factor alpha Gene polymorphism

摘要：

Guillain-Barre syndrome (GBS) is an inflammatory disorder that may implicate proinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) in its pathogenesis. The association between TNF-alpha 308 G/A polymorphism and GBS largely remains unknown. The aim of this study was to investigate the association between TNFalpha 308 G/A polymorphism and GBS in Chinese Han patients. TNF-alpha 308 G/A polymorphism in 150 GBS patients and 150 healthy controls were studied using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Patients with GBS had a significantly higher frequency of TNF-alpha 308AA genotype [odds ratio (OR) = 3.79, 95% confidence interval (CI) = 1.03, 13.94; P = 0.04] than controls. When stratified by the GBS subtype, there was a significantly higher frequency of TNF-alpha 308AA genotype in patients with AMAN (OR = 6.05, 95% CI = 1.45, 25.31; P = 0.01) and AMSAN (OR = 5.56, 95% CI = 1.18, 26.23; P = 0.03) than controls. There was no significant difference in the distribution of each genotype between patients with AIDP and the control group. These data indicated that TNF-alpha 308AAgenotype was associated with a higher risk of GBS in Chinese population, especially to AMAN and AMSAN.

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中科院(CAS)分区：

出版当年[2011]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学

JCR分区：

出版当年[2010]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 2.6 最新[2023版] 2.6 最新五年平均 1.875 出版当年[2010版] 1.728 出版当年五年平均 2.038 出版前一年[2009版] 2.929 出版后一年[2011版]

第一作者：

第一作者机构： [1]Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China;

通讯作者：

通讯机构： [1]Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China; [3]Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, 246 Xuefu Rd, Harbin 150086, Heilongjiang, Peoples R China

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