详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Asphyxial hypoxic preconditioning induces neuroprotective effect via activation of toll-like receptor 4 (TLR4) signal pathway in rats

文献详情

资源类型：

作者：

机构： [a]Department of Anesthesiology, The Second Artillery General Hospital, Beijing 100088, China [b]Department of Gynaecology and Obstetrics, The Second Artillery General Hospital, Beijing 100088, China [c]Department of Anesthesiology, Beijing Sanbo Brain Hospital, Capital Medical University, No. 50, Xiang Shan Yi-ke-song, Haidian District, Beijing 100093, China [d]Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [e]Basic Medical Sciences Academy of Military Medical Sciences of Chinese PLA, Beijing 100071, China

出处：

ISSN：

关键词： Asphyxial cardiac arrest Cerebral ischemic tolerance Hypoxic preconditioning Toll-like receptor 4

摘要：

Hypoxic preconditioning (HP) induces neuroprotective effect against cerebral ischemia, but the mechanism still remains unclear. In this study, we investigated whether the toll-like receptor 4 (TLR4) signal pathway was involved in cerebral ischemic tolerance. According to the treatment of HP and asphyxial cardiac arrest (ACA), rats were assigned to ACA group, HP + ACA group, HP group and Sham group. Rat mortality was 5% in HP + ACA group and 30% in ACA group (P<0.01); neurofunctional scores in HP and HP + ACA group were better than in ACA group (P<0.05). Compared with Sham group, TLR4 mRNA expression, NF-k{cyrillic}B activity and the production of TNF-α and IL-6 in HP or HP + ACA or ACA group were significantly increased. The increase was progressively significant in groups (AHP < AHP + ACA < ACA) (P<0.01). HP induced mild inflammation via activating the TLR4 signal pathway and then further inhibited inflammatory response induced by ACA. © 2011 Academic Journals.

语种：

中科院(CAS)分区：

出版当年[2010]版：

大类 | 4 区综合性期刊

小类 | 4 区综合性期刊

最新[2023]版：

无

第一作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Toll样受体4信号通路在缺氧预处理诱导的大鼠脑缺血耐受中的作用 [2]停通气缺氧预处理减轻窒息致心停跳大鼠脑缺血损伤 [3]The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer [4]Mild hypothermia alleviates excessive autophagy and mitophagy in a rat model of asphyxial cardiac arrest [5]Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4/NF-kappaB pathway [6]Toll-like receptor 2 and-4 are involved in the pathogenesis of the Guillain-Barre syndrome [7]Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion. [8]TLR4基因多态性与中国汉族儿童结核病易感性的关联研究 [9]Toll-like receptor 4 increases intestinal permeability through up-regulation of membrane PKC activity in alcoholic steatohepatitis [10]脓毒症患者单个核细胞Toll样受体4表达与内毒素耐受的关系