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The Pathologic Role of Toll-Like Receptor 4 in Prostate Cancer

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States, [3]Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States, [4]Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States

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关键词： toll-like receptor 4 prostate cancer inflammation carcinogens bacteria

摘要：

Toll-like receptor (TLR) 4 is expressed on normal and malignant prostate epithelial cells. The TLR4 and its downstream signaling pathways mediate innate immune responses in the host against invading pathogens. However, multiple lines of evidence shows that TLR4 expression is increased in prostate tissues from prostate cancer patients, and altered TLR4 signals may promote cancer development, as well as antitumor effects. In this review, we have summarized key features of the TLR4 signaling pathway and its associated immune responses and focused on the pathologic role of TLR4 in prostate carcinogenesis and tumor progression.

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中科院(CAS)分区：

出版当年[2017]版中科院分区表Review为是的期刊

：

大类 | 2 区医学

小类 | 2 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2016]版：

Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 5.7 最新[2023版] 6.8 最新五年平均 6.429 出版当年[2016版] 5.849 出版当年五年平均 5.695 出版前一年[2015版] 5.511 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, China,

通讯作者：

通讯机构： [1]Department of Urology, Xuanwu Hospital, Capital Medical University, Beijing, China,

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