详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine

文献详情

资源类型：

作者：

机构： [a]Peking Union Medical College Hospital, Beijing 100730, China [b]Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China [c]National Center of Nanoscience and Technology, Beijing 100080, China [d]Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China [e]Beijing TianTan Hospital, Beijing 100050, China

出处：

DOI：

ISSN：

关键词： Aluminum Anticancer Immune adjuvant Nanoparticle

摘要：

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more potent than for prophylactic vaccines. Here, we report that compared to conventional alum adjuvant, aluminum oxide nanoparticles (nano-alum) may further enhance the anticancer effects of an immunotherapy that employs tumor cell vaccine (TCV). The average tumor size tends to be lower in animals that receive the combinational treatment of nano-alum and TCV. The anticancer cytotoxicity by the lymphocytes was also significantly higher in the treatment group that received both TCV and nano-alum. These results suggest that nano-alum may potentially serve as a potent immune adjuvant and have prospective applications in anticancer immunotherapy. © Springer-Verlag 2010.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2009]版：

无

最新[2023]版：

大类 | 2 区工程技术

小类 | 3 区纳米科技 3 区肿瘤学

第一作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4(+) T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway [2]Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms [3]Transferrin-Modified Doxorubicin-Loaded Biodegradable Nanoparticles Exhibit Enhanced Efficacy in Treating Brain Glioma-Bearing Rats [4]Ultrasound-triggered nano delivery of lenvatinib for selective immunotherapy treatment against hepatocellular carcinoma [5]Subcapsular renal hematoma after ureteroscopy with holmium:yttrium-aluminum-garnet laser lithotripsy [6]Antitumor activity of dobutamine on human osteosarcoma cells [7]MicroRNA-322 attenuates aluminum maltolate-induced apoptosis in the human SH-SY5Y neuroblastoma cell line [8]北京地区26家医院2011-2013年妇产科铂类抗肿瘤药使用情况分析与比较 [9]《抗肿瘤药物治疗期间肾损伤管理临床实践指南（2022）》解读（六）：透析和肾移植术后患者的抗肿瘤药物治疗 [10]Ultrasound-triggered with ROS-responsive SN38 nanoparticle for enhanced combination cancer immunotherapy