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The effect of aneurismal-wall mechanical properties on patient-specific hemodynamic simulations: two clinical case reports

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

机构: [1]Fudan Univ, Dept Mech & Engn Sci, Shanghai 200433, Peoples R China; [2]Beijing Inst Neurosurg, Beijing 100050, Peoples R China; [3]Capital Med Univ, Dept Biomed Engn, Beijing 100050, Peoples R China
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关键词: Intracranial aneurysm Fluid-structure interaction Computational fluid dynamics Hemodynamics

摘要:
Hemodynamic factors such as the wall shear stress play an important role in the pathogenesis and treatment of cerebral aneurysms. In present study, we apply computational fluid-structure interaction analyses on cerebral aneurysms with two different constitutive relations for aneurismal wall in order to investigate the effect of the aneurismal wall mechanical properties on the simulation results. We carry out these analyses by using two patient-specific models of cerebral aneurysms of different sizes located in different branches of the circle of Willis. The models are constructed from 3D rotational angiography image data and blood flow dynamics is studied under physiologically representative waveform of inflow. From the patient models analyzed in this investigation, we find that the deformations of cerebral aneurysms are very small. But due to the nonlinear character of the Navier-Stokes equations, these small deformations could have significant influences on the flow characteristics. In addition, we find that the aneurismal-wall mechanical properties have great effects on the deformation distribution of the aneurysm, which also affects the wall shear stress distribution and flow patterns. Therefore, how to define a proper constitutive relation for aneurismal wall should be considered carefully in the hemodynamic simulation.

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出版当年[2008]版:
大类 | 4 区 物理
小类 | 4 区 工程:机械 4 区 力学
最新[2023]版:
大类 | 2 区 工程技术
小类 | 3 区 工程:机械 3 区 力学
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出版当年[2007]版:
Q2 ENGINEERING, MECHANICAL Q3 MECHANICS
最新[2023]版:
Q1 ENGINEERING, MECHANICAL Q1 MECHANICS

影响因子: 最新[2023版] 最新五年平均 出版当年[2007版] 出版当年五年平均 出版前一年[2006版] 出版后一年[2008版]

第一作者:
第一作者机构: [1]Fudan Univ, Dept Mech & Engn Sci, Shanghai 200433, Peoples R China;
通讯作者:
通讯机构: [1]Fudan Univ, Dept Mech & Engn Sci, Shanghai 200433, Peoples R China;
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