机构：[1]Affiliated Kailuan Hosp, N China Coal Min Med Coll, Dept Cardiol, Tangshan 063000, Hebei, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China;[3]Capital Med Univ, Beijing 100069, Peoples R China
To explore the association between polymorphism in the ACE I/D gene and blood pressure-lowering response to hydrochlorothiazide (HCTZ) in 829 patients. Methods HCTZ 12.5 mg was taken once a day for six weeks. The blood pressure reduction and ratio reaching target blood pressure were compared in different ACE genotype groups. Results The reduction in SBP of patients carrying DD was greater than that in other groups carrying Ⅱ or ID (12.2 mmHg versus 5.4 mmHg,12.2 mmHg versus 4.4 mmHg, respectively, P＜0.05). The reduction in MAP of patients carrying DD was also greater than that in other groups carrying Ⅱ or ID (6.9 mmHg versus 3.9 mmHg, 6.9 mmHg versus 3.6 mmHg, respectively, P＜0.05). The ratio reaching target blood pressure in DD groups was significantly higher than that in Ⅱ or ID groups (P＜0.05). The pre-treatment SBP, DD genotype, aldosterone levels entered the multi-linear regression model significantly and might affect the reduction of SBP. The pre-treatment DBP, aldosterone levels, DD genotype entered the multi-linear regression model significantly and might affect the reduction of DBP. The pre-treatment MAP, DD genotype, aldosterone levels entered the multi-linear regression model significantly and might affect the reduction of MAP. Conclusion ACE genotyping is associated with blood pressure-lowering response to HCTZ. Specific genotypes might be associated with the response to specific antihypertensive treatment.
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外文
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中科院(CAS)分区：
出版当年[2006]版：
大类|4 区环境科学与生态学
最新[2025]版：
大类|4 区医学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2005]版：
Q3ENVIRONMENTAL SCIENCESQ4PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版：
Q2ENVIRONMENTAL SCIENCESQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
YONG ZHOU,SHOU-LING WU,JIAN-QING LIU,et al.Possible Association of ACE Gene I/D Polymorphism With Blood Pressure——Lowering Response to Hydrochlorothiazide[J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES.2007,20(5):351-356.
APA：
YONG ZHOU,SHOU-LING WU,JIAN-QING LIU,WAN-NIAN LIANG&GAI-FEN LIU.(2007).Possible Association of ACE Gene I/D Polymorphism With Blood Pressure——Lowering Response to Hydrochlorothiazide.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,20,(5)
MLA：
YONG ZHOU,et al."Possible Association of ACE Gene I/D Polymorphism With Blood Pressure——Lowering Response to Hydrochlorothiazide".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 20..5(2007):351-356
