机构：[a]School of Clinical Medicine, Southeast University, Nanjing 210009, China[b]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing 210009, China[c]Department of Psychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing 210009, China[d]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院
The relationship between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and serum ACE activity, as well as amnestic mild cognitive impairment (aMCI), was investigated. The study recruited 90 aMCI patients and 90 matched healthy controls. All subjects underwent an extensive assessment of cognitive function. The ACE gene I/D genotype was determined by polymerase chain reaction. Serum ACE activity was measured using a spectrophotometric technique. The scores obtained by the aMCI patients on the neuropsychological tests were significantly lower than those of the control subjects (all p < 0.01). The genotype (chi(2) = 11.510) and allele (chi(2) = 6.945) frequencies of the ACE gene were significantly different between the aMCI and the control groups (all p < 0.01). The DD genotype (23%) and D-allele (57%) frequencies in the aMCI patients were higher than those in the controls (16% vs. 43%). ACE genotype was correlated with delayed recall in Auditory Verbal Memory Test, delayed recall in Complex Figure Test, Category Fluency Test, and Symbol Digit Modalities Test in all subjects, in which the carriers of the DD and DI genotypes obtained lower scores than those of the II genotype (p < 0.05). A significant difference in the serum ACE level was observed among the three genotypes (DD > DI > II) in both the aMCI and the control groups (all p < 0.01). D-allele may be a genetic risk factor for the development of aMCI to Alzheimer's disease. A high serum ACE level possibly plays an important role in the incidence of aMCI. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
基金：
National Natural Science Foundation of China (No. 30770779)
National Basic Research Program of China (973 Program) (No. 2007CB512308)
National Hi-Tech Research and Development Program of China (863 Program)(No. 2008AA02Z413)
National Natural Science Foundation of China (No. 30825014)
National Key Technologies R&D Program During the 11th Five-year Plan Period (No. 2006BAI02B01
第一作者机构：[a]School of Clinical Medicine, Southeast University, Nanjing 210009, China[b]Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing 210009, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Affiliated ZhongDa Hospital of Southeast, University, No. 87 DingJiaQiao Rd., Nanjing 210009, China.
推荐引用方式(GB/T 7714)：
Zhengsheng Zhang,Linglong Deng,Hui Yu,et al.Association of angiotensin-converting enzyme functional gene I/D polymorphism with amnestic mild cognitive impairment[J].NEUROSCIENCE LETTERS.2012,514(1):131-135.doi:10.1016/j.neulet.2012.02.074.
APA：
Zhengsheng Zhang,Linglong Deng,Hui Yu,Yongmei Shi,Feng Bai...&Zhijun Zhang.(2012).Association of angiotensin-converting enzyme functional gene I/D polymorphism with amnestic mild cognitive impairment.NEUROSCIENCE LETTERS,514,(1)
MLA：
Zhengsheng Zhang,et al."Association of angiotensin-converting enzyme functional gene I/D polymorphism with amnestic mild cognitive impairment".NEUROSCIENCE LETTERS 514..1(2012):131-135
