Objective To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion. Methods Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination. Results BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp. Conclusions Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2006]版：
大类|4 区环境科学与生态学
最新[2023]版：
大类|3 区医学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2005]版：
Q3ENVIRONMENTAL SCIENCESQ4PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者机构：[1]Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Neurosurg Inst, Tiantan Xili 6, Beijing 100050, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Neurosurg Inst, Tiantan Xili 6, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Wan Hong,Zhang Shao-Dong,Li Jun-Hua.Action of Schwann cells implanted in cerebral hemorrhage lesion[J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES.2007,20(1):47-51.
APA：
Wan, Hong,Zhang, Shao-Dong&Li, Jun-Hua.(2007).Action of Schwann cells implanted in cerebral hemorrhage lesion.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,20,(1)
MLA：
Wan, Hong,et al."Action of Schwann cells implanted in cerebral hemorrhage lesion".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 20..1(2007):47-51
