机构：[a]Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases,Beijing, China.[b]Key Laboratory of Remodeling-related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing, China.首都医科大学附属安贞医院[c]Otolaryngological Department of Beijing Anzhen Hospital, Capital Medical University,Beijing, China.临床科室耳鼻咽喉头颈外科首都医科大学附属安贞医院[d]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.临床科室心脏内科中心首都医科大学附属安贞医院
Obstructive sleep apnoea (OSA) is a prevalent sleep disorder considered as an independent risk factor for cardiovascular consequences. It has a strong genetic background and is associated with hypoadiponectinaemia. Target sequencing of whole ADIPONQ gene was performed in 340 participants including 247 patients with OSA and 93 non-OSA participants. Polysomnography was used to diagnose OSA. The associations between variants and OSA were determined by multivariate regression analysis. Thirteen single nucleotide polymorphisms of ADIPOQ were identified in all subjects. Genotype frequencies at rs4686803 (P=. 034), rs3774262 (P=. 034), and rs2082940 (P=. 045) were significantly different between OSA and non-OSA groups. Individuals carrying the CT/TT genotypes of rs4686803, GA/AA genotypes of rs3774262, and CT/TT genotypes of rs1063537 were associated with 2.295-, 2.295- and 2.155-fold increased risk of OSA respectively in dominant model, after adjusting for confounding effects. The subjects with the rs2082940 CC genotype were associated with decreased risk of OSA (OR: 0.455) in recessive model. Additionally, the apnoea-hypopnea index (AHI) was significantly increased in rs3774262 (GA/AA) (P=. 001), rs4686803(CT/TT) (P=. 001), and rs1063537 (CT/TT) (P=. 004) genotype individuals than those with rs3774262 (GG), rs4686803 (CC), and rs1063537 (CC) genotypes, respectively. The AHI was significantly decreased in individuals with ADIPOQ rs2082940 CC genotypes than in those with the CT and TT genotype (P=. 007). Moreover, the stratified analysis found that the genotype of rs3774262 (GA/AA), rs4686803 (CT/TT), and rs1063537 (CT/TT) variants were associated with increased risk of OSA by 2.935-, 2.935- and 2.786-fold in overweight participants. The genotype of rs2082940 CC variants was associated with decreased risk of OSA (OR: 0.373) in overweight participants compared with rs2082940CT/TT genotypes. ADIPOQ variants rs3774262, rs4686803, rs1063537, and rs2082940 were associated with the prevalence of OSA in Chinese Han individuals.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81670331, 81870355]; Beijing Billion Talent Project [2017-A-10]; Beijing Key Laboratory of Upper Airway Dysfunction and Related Cardiovascular Diseases [BZ0377]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201605]; International Science & Technology Cooperation Program of China [2015DFA30160]
第一作者机构：[a]Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases,Beijing, China.[b]Key Laboratory of Remodeling-related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing, China.
通讯作者：
通讯机构：[a]Key Laboratory of Upper Airway Dysfunction-related Cardiovascular Diseases,Beijing, China.[b]Key Laboratory of Remodeling-related Cardiovascular Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing, China.[c]Otolaryngological Department of Beijing Anzhen Hospital, Capital Medical University,Beijing, China.[*1]No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Yunyun Yang,Song Yang,Xiaolu Jiao,et al.Targeted sequencing analysis of the adiponectin gene identifies variants associated with obstructive sleep apnoea in Chinese Han population[J].MEDICINE.2019,98(16):-.doi:10.1097/MD.0000000000015219.
APA：
Yunyun Yang,Song Yang,Xiaolu Jiao,Juan Li,Hao Wu...&Yanwen Qin.(2019).Targeted sequencing analysis of the adiponectin gene identifies variants associated with obstructive sleep apnoea in Chinese Han population.MEDICINE,98,(16)
MLA：
Yunyun Yang,et al."Targeted sequencing analysis of the adiponectin gene identifies variants associated with obstructive sleep apnoea in Chinese Han population".MEDICINE 98..16(2019):-
