机构：[1]Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States[2]Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea[3]Beijing Anzhen Hospital, Capital Medical University, Beijing, China.首都医科大学附属安贞医院
All-trans-retinoic acid (ATRA) has been well described as a positive regulator for early stage of adipocyte differentiation and lipid metabolism and also linked to an in vivo fat-lowering effect in mice. However, not all studies support this association. Our objective was to characterize the action of ATRA in mature adipocytes of mice by ablating RAR signaling through overexpression of a well-characterized dominant negative RARa mutant (RARdn) form specifically in adipocytes. Altered RAR signaling in adipocytes resulted in a significant decrease in ATRA levels in visceral and brown adipose tissues as well as liver tissue. This was linked to significant impairments in glucose clearance and elevated hepatic lipid accumulation for chow diet fed mice, indicating the development of metabolic disease, including hepatic steatosis. In addition, we found that adipose RARdn expression in mice fed a chow diet decreased thermogenesis. We conclude that altered RAR signaling and ATRA levels in adipocytes impacts glucose and lipid metabolism in mice. (C) 2019 Elsevier Inc. All rights reserved.
基金：
NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01DK068437, ROlDK101251]
第一作者机构：[1]Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States[2]Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea[*1]Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States.
通讯作者：
通讯机构：[1]Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States[2]Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea[*1]Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, United States.
推荐引用方式(GB/T 7714)：
Lee Seung-Ah,Jiang Hongfeng,Feranil Jun B.,et al.Adipocyte-specific expression of a retinoic acid receptor alpha dominant negative form causes glucose intolerance and hepatic steatosis in mice[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2019,514(4):1231-1237.doi:10.1016/j.bbrc.2019.05.075.
APA：
Lee, Seung-Ah,Jiang, Hongfeng,Feranil, Jun B.,Brun, Pierre Jacques&Blaner, William S..(2019).Adipocyte-specific expression of a retinoic acid receptor alpha dominant negative form causes glucose intolerance and hepatic steatosis in mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,514,(4)
MLA：
Lee, Seung-Ah,et al."Adipocyte-specific expression of a retinoic acid receptor alpha dominant negative form causes glucose intolerance and hepatic steatosis in mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 514..4(2019):1231-1237
