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Mechanical contraction to guide CRT left-ventricular lead placement instead of electrical activation in myocardial infarction with left ventricular dysfunction: An experimental study based on non-invasive gated myocardial perfusion imaging and invasive electroanatomic mapping

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资源类型：
作者：
Jianfeng Wang, [a] * ; Yuetao Wang, [a,*1] ; Minfu Yang, [b] ; Shan Shao, [c] ; Yi Tian, [d] ; Xiaoliang Shao, [a] ; Shengdeng Fan, [e] ; Feifei Zhang, [a] ; Wei Yang, [a] ; Wenchong Xin, [a] ; Haipeng Tang,[f] ; Min Xu, [g] ; Ling Yang, [c] ; Xiaosong Wang, [a] ; Weihua Zhou, [f] ;
机构： [a]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China [b]Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China [c]Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, China [d]Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [e]Department of Anesthesiology, The Third Affiliated Hospital of Soochow University, Changzhou, China [f]School of Computing, University of Southern Mississippi, Long Beach, MS [g]Department of Echocardiogram, The Third Affiliated Hospital of Soochow University, Changzhou, China
出处：
DOI： 10.1007/s12350-019-01710-2
ISSN：

关键词： Cardiac resynchronization therapy dyssynchrony gated SPECT latest mechanical contraction myocardial infarction

摘要：
Background: Whether the region of the latest electrical activation (LEA) corresponds with the segment of the latest mechanical contraction (LMC) in ischemic cardiomyopathy (ICM) is uncertain. We aimed to investigate the relationship between the left-ventricular (LV) viable segments with LEA and with LMC after myocardial infarction (MI) and analyze the acute hemodynamic responses (dP/dtmax) after cardiac resynchronization therapy (CRT) pacing at different LV sites. Methods and results: Bama suckling pigs (n = 6) were subjected to create MI models. Both gated myocardial perfusion imaging (GMPI) and electroanatomic mapping (EAM) were performed successfully before MI and 4 weeks after MI. LMC was assessed by phase analysis of GMPI, while LEA was evaluated by EAM. The dP/dtmax was measured before CRT and when the CRT LV electrode was implanted in viable segments of LMC, viable segments of lateral wall and scar, respectively. The viable segments of LEA were consistent with the sites of LMC for five in six cases. The dP/dtmax increased significantly compared with that before CRT when the CRT LV electrode was implanted in viable segments of LMC (1103.33 ± 195.76 vs 717.83 ± 80.74 mmHg·s−1, P =.001), which was also significantly higher than in viable segments of lateral wall (751.17 ± 105.62 mmHg·s−1, P =.000) and scar (679.50 ± 60.87 mmHg·s−1, P =.001). Conclusions: Non-invasive GMPI may be a better option than invasive EAM for guiding LV electrode implantation for CRT in ICM. © 2019, American Society of Nuclear Cardiology.

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外文
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出版当年[2018]版：
大类 | 2 区 医学
小类 | 2 区 核医学 3 区 心脏和心血管系统
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 核医学 4 区 心脏和心血管系统
第一作者：
第一作者机构： [a]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China
通讯作者：
通讯机构： [a]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China [*1]Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China
推荐引用方式(GB/T 7714)：
Jianfeng Wang ,Yuetao Wang ,Minfu Yang ,et al.Mechanical contraction to guide CRT left-ventricular lead placement instead of electrical activation in myocardial infarction with left ventricular dysfunction: An experimental study based on non-invasive gated myocardial perfusion imaging and invasive electroanatomic mapping[J].JOURNAL OF NUCLEAR CARDIOLOGY.2019,doi:10.1007/s12350-019-01710-2.
APA：
Jianfeng Wang,,Yuetao Wang,,Minfu Yang,,Shan Shao,,Yi Tian,...&Weihua Zhou,.(2019).Mechanical contraction to guide CRT left-ventricular lead placement instead of electrical activation in myocardial infarction with left ventricular dysfunction: An experimental study based on non-invasive gated myocardial perfusion imaging and invasive electroanatomic mapping.JOURNAL OF NUCLEAR CARDIOLOGY,,
MLA：
Jianfeng Wang,,et al."Mechanical contraction to guide CRT left-ventricular lead placement instead of electrical activation in myocardial infarction with left ventricular dysfunction: An experimental study based on non-invasive gated myocardial perfusion imaging and invasive electroanatomic mapping".JOURNAL OF NUCLEAR CARDIOLOGY .(2019)

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