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Beyond lipid-lowering: progress in researches for Xuezhikang in cardiovascular protection and its mechanisms

血脂康降脂以外的心血管保护作用及机制研究进展

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收录情况: ◇ 统计源期刊 ◇ 北大核心 ◇ CSCD-C

机构: [1]南华大学附属郴州医院心血管内科 [2]河南科技大学第二附属医院心血管内科 [3]首都医科大学附属北京安贞医院高血压科
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关键词: Atherosclerosis Cardiovascular benefit Cardiovascular disease Molecular mechanisms Xuezhikang

摘要:
Cardiovascular disease (CVD) has been one of the leading causes of mortality worldwide, and atherosclerosis (As) is a common pathogenic basis for CVD. Xuezhikang is a purified extract of fermented red yeast rice with benefits to improvement of As. Apart from being a safe and effective lipid-lowering drug, Xuezhikang has drawn growing awareness due to its cardiovascular protection beyond lipid modulation. Studies have shown that Xuezhikang exerts its anti-atherosclerotic function via mechanisms as the following: regulation of endothelial function, protection for endothelial progentitor cells, alleviation of oxidative stress and attenuation of inflammation. This article reviews the research progress of Xuezhikang on cardiovascular protection against atherosclerosis from the above aspects. © 2019, Chinese Journal of New Drugs Co. Ltd. All right reserved.

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第一作者机构: [1]南华大学附属郴州医院心血管内科
通讯作者:
通讯机构: [3]首都医科大学附属北京安贞医院高血压科
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