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Calumenin DNA methylation and gene expression in viral myocarditis

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R. China [2]Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China [3]First Clinical Medical of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China.

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关键词： DNA methylation calumenin viral myocarditis ERS

摘要：

The main death reason is inflammatory response of myocardial tissue caused a sharp decline in myocardial contractility and heart failure. At present, viral myocarditis with heart failure is lack of effective and specific treatment. Basic and clinical studies have shown that intervention apoptosis is an effective way to prevent and cure heart failure. The mechanism of apoptosis is complex, endoplasmic reticulum (ER) stress is a new apoptotic signal transduction pathway was been found. In this study, the apoptosis could be increased in mice with CVB3 treatment. The ER stress related proteins GRP78, ATF4, CHOP were up-regulated in VMC. The mechanism of VMC regulated ERS induced apoptosis was identified. Calumenin protein could relieve ERS induced apoptosis in viral myocarditis in vivo. The DNA methylation of calumenin was analyzed in CON and VMC, however, we found VMC down-regulate the expression of calumenin unrelated with DNA methylation of calumenin.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

最新[2023]版：

无

JCR分区：

出版当年[2016]版：

Q3 PATHOLOGY Q4 ONCOLOGY

最新[2023]版：

Q3 PATHOLOGY Q4 ONCOLOGY Q4 PATHOLOGY

影响因子： 1.2 最新[2023版] 1.3 最新五年平均 1.706 出版当年[2016版] 1.779 出版当年五年平均 1.581 出版前一年[2015版] 1.396 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R. China

共同第一作者：

通讯作者：

通讯机构： [2]Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China [3]First Clinical Medical of Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, P.R. China. [*1]Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. China [*2]First Clinical Medical of Inner Mongolia University for Nationali- ties, 1472 Holin He Street, Tongliao 028002, Inner Mongolia, P.R. China.

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