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DNA methylation clocks for estimating biological age in Chinese cohorts

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
Zheng Zikai[1,2] * ; Li Jiaming[1,2] * ; Liu Tianzi[1,3] * ; Fan Yanling[1] * ; Zhai Qiao-Cheng[4,5] * ; Xiong Muzhao[1,2] * ; Wang Qiao-Ran[1,2] ; Sun Xiaoyan[1,2] ; Zheng Qi-Wen[1] ; Che Shanshan[1,2] ; Jiang Beier[4] ; Zheng Quan[4] ; Wang Cui[1,2] ; Liu Lixiao[1,2] ; Ping Jiale[1,2] ; Wang Si[6,7,8] ; Gao Dan-Dan[4] ; Ye Jinlin[4] ; Yang Kuan[1,2] ; Zuo Yuesheng[1,2] ; Ma Shuai[9,10,11,12,8] ; Yang Yun-Gui[1,2] ; Qu Jing[13,10,2,11,12,8] ; Zhang Feng[5] ; Jia Peilin[1,2,14] ; Liu Guang-Hui[9,10,2,11,12,6,7,8] ; Zhang Weiqi[1,2,11,8] ;
机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. [2]University of Chinese Academy of Sciences, Beijing 100049, China. [3]CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China. [4]The Joint Innovation Center for Engineering in Medicine, the Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou 324000, China. [5]Division of Orthopaedics, the Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou 324000, China. [6]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China. [7]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [8]Aging Biomarker Consortium, Beijing 100101, China. [9]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [10]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [11]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. [12]Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101, China. [13]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [14]National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
出处：
DOI： 10.1093/procel/pwae011
ISSN：

关键词： DNA methylation aging clock aging age prediction

摘要：
Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation at specific CpG sites. However, available DNA methylation (DNAm) age predictors are based on datasets with limited ethnic representation. Moreover, a systematic comparison between DNAm data and other omics datasets has not yet been performed. To address these knowledge gaps, we generated and analyzed DNA methylation datasets from two independent Chinese cohorts, revealing age-related DNAm changes. Additionally, a DNA methylation (DNAm) aging clock (iCAS-DNAmAge) and a group of DNAm-based multi-modal clocks for Chinese individuals were developed, with most of them demonstrating strong predictive capabilities for chronological age. The clocks were further employed to predict factors influencing aging rates. The DNAm aging clock, derived from multi-modal aging features (compositeAge-DNAmAge), exhibited a close association with multi-omics changes, lifestyles, and disease status, underscoring its robust potential for precise biological age assessment. Our findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace, providing basis for evaluating aging intervention strategies.© The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.

基金：
This work was supported by the National Key Research and Development Program of China (2021YFF1201000, 2022YFA1103700), the Quzhou Technology Projects (2022K46), the National Natural Science Foundation of China (Grant Nos. 32121001, 81921006, 82125011, 92149301, 82361148131,82192863), the National Key Research and Development Program of China (2020YFA0804000, 2020YFA0112200, the STI2030-Major Projects-2021ZD0202400, 2021YFA1101000), the National Natural Science Foundation of China (Grant Nos. 92168201, 92049304, 92049116, 82122024, 82071588, 32000510, 82361148130 82271600, 82322025, 82330044, 32341001), CAS Project for Young Scientists in Basic Research (YSBR-076, YSBR-012), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB38010400), the Science and Technology Service Network Initiative of Chinese Academy of Sciences (KFJ-STS-QYZD-2021-08-001), the Beijing Natural Science Foundation (Z230011,5242024) the Informatization Plan of Chinese Academy of Sciences (CAS-WX2021SF-0301, CAS-WX2022SDC-XK14, CAS-WX2021SF-0101), New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), Youth Innovation Promotion Association of CAS (E1CAZW0401, 2022083), Excellent Young Talents Program of Capital Medical University (12300927), the Project for Technology Development of Beijing-affiliated Medical Research Institutes (11000023T000002036310), Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105), and Young Elite Scientists Sponsorship Program by CAST (2021QNRC001),Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (JYY202X-X).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. [2]University of Chinese Academy of Sciences, Beijing 100049, China.
共同第一作者：
通讯作者：
通讯机构： [1]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. [2]University of Chinese Academy of Sciences, Beijing 100049, China. [6]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China. [7]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [8]Aging Biomarker Consortium, Beijing 100101, China. [9]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [10]Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [11]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. [12]Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101, China. [13]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [14]National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
推荐引用方式(GB/T 7714)：
Zheng Zikai,Li Jiaming,Liu Tianzi,et al.DNA methylation clocks for estimating biological age in Chinese cohorts[J].PROTEIN & CELL.2024,15(8):575-593.doi:10.1093/procel/pwae011.
APA：
Zheng Zikai,Li Jiaming,Liu Tianzi,Fan Yanling,Zhai Qiao-Cheng...&Zhang Weiqi.(2024).DNA methylation clocks for estimating biological age in Chinese cohorts.PROTEIN & CELL,15,(8)
MLA：
Zheng Zikai,et al."DNA methylation clocks for estimating biological age in Chinese cohorts".PROTEIN & CELL 15..8(2024):575-593

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