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Increased levels of interleukin-22 in thoracic aorta and plasma from patients with acute thoracic aortic dissection

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资源类型：

收录情况： ◇ SCIE

作者：
Jing Ye[a,b] * ; Menglong Wang[a] * ; Huimin Jiang[a] * ; Qingwei Ji[c] ; Ying Huang[b] ; Jianfang Liu[a] ; Tao Zeng[b] ; Yao Xu[a] ; Zhen Wang[a] ; Yingzhong Lin[a,b,*1] ; Jun Wan[a,*2] ;
机构： [a]Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China [b]Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China [c]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China
出处：
DOI： 10.1016/j.cca.2017.10.033
ISSN：

关键词： Thoracic aortic dissection Interleukin-22 Inflammation

摘要：
Background: Interleukin (IL)-22 plays important roles in the development of arterial disease, including atherosclerosis and hypertension. However, the relationship between IL-22 and acute thoracic aortic dissection (TAD) remains unknown. Methods: Blood samples were collected from patients with chest pain who underwent computed tomography angiography of the thoracic aorta but had no known preoperative diagnosis of coronary artery disease, peripheral artery disease, arthritis, and/or membranous nephropathy. Patients were divided into non-AD (NAD) and TAD groups, and the plasma concentrations of IL-22, IL-6 and tumor necrosis factor (TNF)-alpha were measured. In addition, aortic tissue samples from acute TAD patients and normal donors were collected, and the expression levels of IL-22 and IL-22 receptor 1 (IL-22R1) were measured. Results: IL-22, IL-6 and TNF-alpha levels were significantly higher in acute TAD patients than in NAD patients (IL-22, NAD group: 27.0 (19.1, 38.6) pg/ml vs. TAD group: 32.9 (20.6, 58.3) pg/ml, p < 0.0001). The correlation analysis showed that IL-22 levels were positively correlated with levels of IL-6, TNF-alpha, fasting glucose, blood pressure, white blood cells, C-reactive proteins and D-dimers. Binary logistic regression analyses showed that IL 22 was independently associated with the presence of acute TAD (OR 1.169, 95% CI 1.069 to 1.277; p = 0.001). In addition, compared with aortic tissue of normal controls, TAD aortas showed increased expression of IL-22 and IL-22R1, especially in the torn section (IL-22, non-torn section: 2.8 +/- 0.5/HPF vs. torn section 2.8 +/- 0.5/HPF,p < 0.001). Additionally, macrophage but not T lymphocyte infiltration was significantly increased in the torn section (Macrophage, non-torn section: 2.2 +/- 0.6/HPF vs. torn section 5.7 +/- 1.2/HPF, p < 0.001; T lymphocyte, non-torn section: 2.7 +/- 0.9/HPF vs. torn section 2.4 +/- 0.5/HPF, p = 0.28), as evidenced by increased positive staining for the macrophage marker CD68, as opposed to the T cell marker CD3. Conclusion: IL-22 levels may correlate with the presence of acute TAD.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81360055, 81170208, 81560085, 81460081]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 2 区 医学实验技术
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 医学实验技术
JCR分区：
出版当年[2016]版：
Q2 MEDICAL LABORATORY TECHNOLOGY
最新[2023]版：
Q2 MEDICAL LABORATORY TECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [a]Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China [b]Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China [b]Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China [*1]Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. [*2]Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
推荐引用方式(GB/T 7714)：
Jing Ye,Menglong Wang,Huimin Jiang,et al.Increased levels of interleukin-22 in thoracic aorta and plasma from patients with acute thoracic aortic dissection[J].CLINICA CHIMICA ACTA.2018,486:395-401.doi:10.1016/j.cca.2017.10.033.
APA：
Jing Ye,Menglong Wang,Huimin Jiang,Qingwei Ji,Ying Huang...&Jun Wan.(2018).Increased levels of interleukin-22 in thoracic aorta and plasma from patients with acute thoracic aortic dissection.CLINICA CHIMICA ACTA,486,
MLA：
Jing Ye,et al."Increased levels of interleukin-22 in thoracic aorta and plasma from patients with acute thoracic aortic dissection".CLINICA CHIMICA ACTA 486.(2018):395-401

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