机构：[1]Guang’an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China[2]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China[3]Beijing University of Chinese Medicine, Beijing 100029, China[4]Department of Cardiology, Beijing An Zhen Hospital of the Capital University of Medical Sciences, Beijing 100853, China临床科室心脏内科中心首都医科大学附属安贞医院[5]Community healthcare center of Xiluoyuan, Beijing, 100077, China
Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious diseases and is an increasing health-care burden. AF is associated with an excess amount of reactive oxygen species. In this review, we summarize several possible reactive oxygen species pathways that induce AF based on atrial electrical and structural remodeling data. The sources and factors implicated in AF-related oxidative stress include NADPH oxidase activation, calcium overloading and mitochondrial damage, angiotensin system activation, nitric oxide synthase uncoupling, and xanthine oxidase activation-associated cardiovascular conditions. Scavenging oxidative stress markers and related substances are essential aspects of these molecular mechanisms, and may be a therapeutic target in AF.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673899, 81430098]; National high-level talent special support plan [W02020052]; Clinical base project of State Administration of Traditional Chinese medicine of China [JDZX2015007]; State Key Development Program of China [2017YFC1700400]
第一作者机构：[1]Guang’an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China[2]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China[5]Community healthcare center of Xiluoyuan, Beijing, 100077, China
共同第一作者：
通讯作者：
通讯机构：[1]Guang’an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China[2]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China[*1]Guang’an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China[*2]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
推荐引用方式(GB/T 7714)：
Xiaomeng Ren,Xiaofeng Wang,Mengchen Yuan,et al.Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation[J].CURRENT PHARMACEUTICAL DESIGN.2018,24(26):3062-3071.doi:10.2174/1381612824666180903144042.
APA：
Xiaomeng Ren,Xiaofeng Wang,Mengchen Yuan,Chao Tian,Huilong Li...&Yanwei Xing.(2018).Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation.CURRENT PHARMACEUTICAL DESIGN,24,(26)
MLA：
Xiaomeng Ren,et al."Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation".CURRENT PHARMACEUTICAL DESIGN 24..26(2018):3062-3071
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