当前位置: 首页 > 详情页

Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review

文献详情

资源类型:

收录情况: ◇ SCIE

机构: [1]SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, 270 Farber Hall, Buffalo, NY 14214 USA; [2]Anzhen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China; [3]Hang Tian Gen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
出处:
ISSN:

关键词: Biomarkers pregnancy mechanisms oxidative stress inflammation

摘要:
Purpose: This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes. Methods: We searched PubMed and Google scholar databases to find articles. Results and conclusions: We found 29 articles, mostly consisting of cohort studies. Interpolation models were most frequently used to assess exposure. The most consistent positive association was between polycyclic aromatic hydrocarbon (PAH) exposure during entire pregnancy and cord blood PAH DNA adducts. Exposure to particulate matter (PM) and nitrogen dioxide (NO2) showed consistent inverse associations with mitochondrial DNA (mtDNA) content, particularly in the third trimester of pregnancy. No single pollutant showed strong associations with all the biomarkers included in this review. C-reactive proteins (CRPs) and oxidative stress markers increased, whereas telomere length decreased with increasing air pollution exposure. Placental global DNA methylation and mtDNA methylation showed contrasting results with air pollution exposure, the mechanism behind which is unclear. Most studies except those on PAH DNA adducts and mtDNA content provided insufficient evidence for characterizing a critical exposure window. Further research using biomarkers is warranted to understand the relationship between air pollution and perinatal outcomes.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2016]版:
大类 | 3 区 医学
小类 | 3 区 生物工程与应用微生物 3 区 毒理学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 毒理学
JCR分区:
出版当年[2015]版:
Q3 TOXICOLOGY Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2023]版:
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 TOXICOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者:
第一作者机构: [1]SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, 270 Farber Hall, Buffalo, NY 14214 USA;
通讯作者:
通讯机构: [1]SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, 270 Farber Hall, Buffalo, NY 14214 USA;
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:16461 今日访问量:0 总访问量:871 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持:重庆聚合科技有限公司 地址:北京市西城区长椿街45号宣武医院