Mitofusin-2 (MFN2) is a mitochondrial protein associated with mitochondrial fusion process. It was initially identified as a hyperplasia suppressor and implicated in Charcot-Marie-Tooth disease. Recent studies showed that MFN2 played important roles in the development of multiple tumors. Here we examined MFN2 expression in 30 lung adenocarcinoma samples and revealed that the expression of MFN2 was significantly higher in lung adenocarcinoma tissues as compared to adjacent normal tissues. We then investigated the impact of MFN2 knockdown on A549 human lung adenocarcinoma cells and showed that cell proliferation, cell cycle and invasion behavior were all deregulated by MFN2 knockdown. And deregulation of cell cycle pathway after MFN2 knockdown was confirmed by microarray analysis. Furthermore, microarray analysis also revealed that different oncogenes such as RAP1A, RALB and ITGA2 were oppositely regulated by MFN2, which provided molecular clues for the paradoxical functions of MFN2 in tumor development. Taken together, our study unraveled the tumor-promoting functions of MFN2 in lung adenocarcinoma and implicated that the role of MFN2 in cancer development might be more complicated than expected and should be explored in detail in the future.
基金：
National Natural Science foundation of ChinaNational Natural Science Foundation of China [81201839, 81101770]; Shanghai Municipal Commission of Health and Family Planning [20124Y108]; Excellent Young Teachers Program of Shanghai Jiaotong University School of Medicine; Science and Technology Foundation of Shanghai Chest Hospital [YZ12-03]; National High Technology Research and Development ProgramNational High Technology Research and Development Program of China [2008AA02Z441]
通讯机构：[1]Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Pulm, Shanghai 200030, Peoples R China;[4]Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Pulm, 241 West Huaihai Rd, Shanghai 200030, Peoples R China
推荐引用方式(GB/T 7714)：
Lou Yuqing,Li Rong,Liu Jielin,et al.Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma[J].MEDICAL ONCOLOGY.2015,32(4):-.doi:10.1007/s12032-015-0515-0.
APA：
Lou, Yuqing,Li, Rong,Liu, Jielin,Zhang, Yanwei,Zhang, Xueyan...&Han, Baohui.(2015).Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma.MEDICAL ONCOLOGY,32,(4)
MLA：
Lou, Yuqing,et al."Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma".MEDICAL ONCOLOGY 32..4(2015):-
