Objective: The correlation between GATA4 gene polymorphism and congenital heart disease (CHD) was analyzed. Method: Clinical data and blood samples were collected from 350 CHD patients who were treated at the Department of Cardiology in Beijing Anzhen Hospital. The control group consisted of 350 healthy subjects receiving physical examination at our hospital during the same period. Polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis for locus rs11392441 of GATA4 gene. Results: Polymorphism of locus rs1139244 of GATA4 gene was detected in CHD patients. The distribution frequencies of GG genotype and G allele were significantly higher than those of the control group. Conclusion: Polymorphism of locus rs1139244 of GATA4 gene was correlated with CHD.
第一作者机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Ward 4, Beijing 100029, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Ward 4, Beijing 100029, Peoples R China;[2]Capital Med Univ, Beijing Anzhen Hosp, Ward 4, 2 Anzhen Rd, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Xue-Yong,Jing Xiao-Yong,Chen Zhe,et al.Correlation between GATA4 gene polymorphism and congenital heart disease[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2015,8(9):16733-16736.
APA：
Yang, Xue-Yong,Jing, Xiao-Yong,Chen, Zhe&Liu, Ying-Long.(2015).Correlation between GATA4 gene polymorphism and congenital heart disease.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,8,(9)
MLA：
Yang, Xue-Yong,et al."Correlation between GATA4 gene polymorphism and congenital heart disease".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8..9(2015):16733-16736
