机构:[1]Beijing 302 Hosp, PLA 302 Hosp, Liver Failure Therapy & Res Ctr, Beijing 100039, Peoples R China;[2]Capital Med Univ, Beijing Anzhen Hosp, Emergency Dept, Beijing, Peoples R China;临床科室急诊危重症中心首都医科大学附属安贞医院[3]Acad Mil Med Sci, Postgrad Div, Beijing, Peoples R China;[4]Beijing 302 Hosp, PLA 302 Hosp, Liver Failure Therapy & Res Ctr, 100 West Fourth Ring Middle Rd, Beijing 100039, Peoples R China
Till date, comparison of clinical characteristics in acute liver failure (ALF) between adults and children has not been performed. In this study, authors retrospectively collected data on adult acute liver failure (AALF) and pediatric acute liver failure (PALF) in seven hospitals in different areas of China from January 2007 through December 2012. A total of 177 AALF cases and 32 PALF cases were eventually included. Several vital clinical variables were significantly different between AALF and PALF, including serum alkaline phosphatase, serum creatinine, serum urea nitrogen, serum lactate dehydrogenase, platelet count, prothrombin activity, international normalized ratio and blood ammonia. It is concluded that experience from AALF could not be proper for PALF.