Background Repeat percutaneous coronary intervention (PCI) is associated with unfavorable prognosis in patients with coronary artery disease,but there is a current lack of related systematic cross-sectional studies in China.The survey was to investigate a real world of repeat PCIs and their associated factors during the drug eluting stent era in a Beijing high volume center.Methods A comprehensive review of the institution's database between January 2006 and July 2009 was conducted.Demographic information,concomitant diseases,peri-procedure laboratory examinations and angiographic features were collected consecutively.Multivariate Logistic regression analysis was undertaken to explore the risk factors associated with repeat PCIs.Results A total of 13404 patients were included in the analysis.Of which,1946 patients (14.5％) had prior PCI procedure.More males patients had previous PCI than the females (15.7％ vs 10.9％,P ＜0.001).After adjustment for age,gender,concomitant diseases,angiographic and procedural factors,a multivariate model showed that male,diabetes,hyperlipidemia and previous myocardial infarction,left main disease were identified as independent risk factors of repeat PCIs.Of which,previous myocardial infarction (odds ratio:2.58,95％ confidence interval:2.27-2.92)was highly related with repeat PCIs.Conclusion The frequency of repeat PCIs was 14.5％ in this cross-sectional investigation,and their associated factors included male,diabetes,hyperlipidemia and previous MI and left main disease during drug eluting stent era.