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Effectiveness of Triptolide-Coated Stent on Decreasing Inflammation and Attenuation of Intimal Hyperplasia in a Pig After Coronary Angioplasty

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资源类型：

收录情况： ◇ SCIE

作者：
Ge, HaiLong[1] * ; Zhou, YuJie[1] ; Ma, HanYing[1] ; Liu, Lei[2] ; Liu, XiaoLi[1] ; Wang, ZhiJian[1] ; Yang, ShiWei[1] ; Nie, Bin[1] ; Jia, Dean[1] ;
机构： [1]Capital Med Univ, Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China; [2]Chinese Acad Med Sci, Fu Wai Hosp, Dept Pathol, Beijing 100037, Peoples R China
出处：
DOI： 10.1177/0003319710385337
ISSN：

关键词： inflammation neointimal hyperplasia triptolide restenosis stent

摘要：
Objective: The study is to test the efficacy of triptolide-coated stent on anti-inflammatory and inhibiting intimal hyperplasia in preventing restenosis. Methods: A total of 15 triptolide-coated stents (TCSs), 12 drug-eluting stents (DESs), and 12 bare metal stents (BMSs) were deployed in porcine coronary arteries. Coronary angiography, histopathologic and inflammatory markers levels were analyzed at 4 week after stenting. Results: At 4-week follow-up, quantitative coronary angiography (QCA) showed that minimum lumen diameter was greater, and percentage stenosis and late lumen loss in TCS group and DES group were less than that of BMS group. Compared to BMS group, injury and inflammation score in TCS group and DES group were decreased, neointimal area significantly reduced and lumen area enlarged in TCS, DES group as well. Conclusion: Triptolide-coated stent showed the effect of preventing restenosis via inhibition of neointimal hyperplasia and anti-inflammation acts after coronary angioplasty.

基金：
Capital medical Foundation
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类 | 4 区 医学
小类 | 4 区 外周血管病
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 外周血管病
JCR分区：
出版当年[2009]版：
Q4 PERIPHERAL VASCULAR DISEASE
最新[2023]版：
Q2 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2023版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

第一作者：
第一作者机构： [1]Capital Med Univ, Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China;
通讯作者：
通讯机构： [1]Capital Med Univ, Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China;
推荐引用方式(GB/T 7714)：
Ge HaiLong,Zhou YuJie,Ma HanYing,et al.Effectiveness of Triptolide-Coated Stent on Decreasing Inflammation and Attenuation of Intimal Hyperplasia in a Pig After Coronary Angioplasty[J].ANGIOLOGY.2011,62(3):265-269.doi:10.1177/0003319710385337.
APA：
Ge, HaiLong,Zhou, YuJie,Ma, HanYing,Liu, Lei,Liu, XiaoLi...&Jia, Dean.(2011).Effectiveness of Triptolide-Coated Stent on Decreasing Inflammation and Attenuation of Intimal Hyperplasia in a Pig After Coronary Angioplasty.ANGIOLOGY,62,(3)
MLA：
Ge, HaiLong,et al."Effectiveness of Triptolide-Coated Stent on Decreasing Inflammation and Attenuation of Intimal Hyperplasia in a Pig After Coronary Angioplasty".ANGIOLOGY 62..3(2011):265-269

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