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Extracellular vesicles as an emerging tool for the early detection of Alzheimer's disease

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053 [2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China, 100053 [3]Beijing Institute of Geriatrics, Beijing, China, 100053 [4]National Clinical Research Center for Geriatric Disorders, Beijing, China, 100053 [5]Beagle Biotechnology Company Limited, Changzhou, Jiangsu, China, 213000

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关键词： Alzheimer's disease Biomarker Exosomes Extracellular vesicles β-amyloid

摘要：

Alzheimer's disease (AD) is characterized by a series of interacting pathophysiological cascades, including the aggregation of β-amyloid plaques and the formation of neurofibrillary tangles derived from hyperphosphorylated tau proteins. AD is the cause of approximately 70 % of dementia, an irreversible and untreatable syndrome at its late stage. Hence, more efforts should be devoted to identifying at-risk or preclinical AD populations for early intervention and the improved design of drug trials. The exosome, a nanoscale subtype of extracellular vesicle that serves as a cell-to-cell communication messenger, is an emerging liquid biopsy tool for various diseases including AD. Recently, it has been discovered that brain-derived exosomes can flow through the blood-brain barrier to the peripheral blood, containing important protein and nucleic acid biomarkers that are associated with the pathogenesis and progression of AD. Other reports showed a strong involvement of exosomes in synaptic function, insulin resistance, and neuroinflammation, among others. Here, we summarize those studies and assess the value of exosomes as an emerging tool for the early detection of AD in conjunction with the current clinical diagnosis paradigm. © 2019 Elsevier B.V.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区老年医学 4 区细胞生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区老年医学

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出版当年[2017]版：

Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY Q2 CELL BIOLOGY

影响因子： 5.3 最新[2023版] 5.5 最新五年平均 3.748 出版当年[2017版] 3.663 出版当年五年平均 3.087 出版前一年[2016版] 3.603 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053 [2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China, 100053 [3]Beijing Institute of Geriatrics, Beijing, China, 100053 [4]National Clinical Research Center for Geriatric Disorders, Beijing, China, 100053 [*1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053. [*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053

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