OBJECTIVE: Current studies reporting the association between VDR polymorphisms and susceptibility to hypertension are controversial. This meta-analysis aims to obtain a precise correlation estimate between VDR polymorphisms and susceptibility to hypertension. MATERIALS AND METHODS: Relevant studies were searched in PubMed. Web of Science, CNRI. Wanfang, and VIP using the keywords as "Vitamin D receptor, hypertension", "Vitamin D receptor polymorphism, hypertension", and "VDR, hypertension". ORs and corresponding 95%CI of eligible studies were calculated using RevMan5.3 and STATA12.0. RESULTS: Seven independent studies reporting the association between VDR gene polymorphisms and hypertension were enrolled. VDR rs1544410 (Bsml) was associated with susceptibility to hypertension. The frequency of VDR Bsml AA genotype decreased in hypertension patients compared with healthy controls. The population carrying VDR Bsml AA genotype had lower susceptibility to hypertension relative to those carrying GA or GG genotype (OR = 0.69, 95% CI = 0.54-0.89. p = 0.005). Meanwhile. the frequency of A allele was higher in the case group than that of control group (OR = 0.83, 95% CI = 0.69-0.99, p = 0.04). No significant correlation was found between VDR Fokl or VDR Apal with susceptibility to hypertension. CONCLUSIONS: VDR Bsml gene polymorphism is closely related to the susceptibility to hypertension.
基金：
Special Fund of The Pediatric Medical Coordinated Development Center of Beijing Municipal Administration [XTYB201819]; Research on the application of clinical characteristics of the Beijing Municipal Science and Technology Commission [Z171100001017048]; Beijing Municipal Education Commission Science and Technology Plan General Project [KM201910025010]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [GPY201814]; Beijing Children's Hospital
第一作者机构：[1]Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Cardiovasc Surg 2, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Cardiovasc Surg 2, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Zhu Y-B,Li Z-Q,Ding N.,et al.The association between vitamin D receptor gene polymorphism and susceptibility to hypertension: a meta-analysis[J].European review for medical and pharmacological sciences.2019,20(20):9066-9074.doi:10.26355/eurrev_201910_19309.
APA：
Zhu, Y-B,Li, Z-Q,Ding, N.&Yi, H-L.(2019).The association between vitamin D receptor gene polymorphism and susceptibility to hypertension: a meta-analysis.European review for medical and pharmacological sciences,20,(20)
MLA：
Zhu, Y-B,et al."The association between vitamin D receptor gene polymorphism and susceptibility to hypertension: a meta-analysis".European review for medical and pharmacological sciences 20..20(2019):9066-9074
