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Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma

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机构： [1]Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191 [2]Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853 [3]Department of Pathology, Beijing Tiantan Hospital Affiliated with Capital Medical University, Beijing 100050 [4]Department of Respiratory Medicine, The First Affiliated Hospital of Gannan Medical University,Ganzhou, Guangdong 341000 [5]Department of Pathology, Chinese People'sLiberation Army General Hospital, Beijing 100853, P.R. China

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关键词： Exosome complex genes Gene expression profile Mantle cell lymphoma RNA degradation

摘要：

Exosome complex (EXOSC) genes, which encode a multi-protein intracellular complex, mediate the degradation of various types of RNA molecules. EXOSCs, also known as polymyositis/scleroderma complexes, exist in eukaryotic cells and archaea, and primarily mediate 3' to 5'mRNA degradation. However, how EXOSC genes are implicated in processes of B-cell immune-associated pathways and B-cell tumorigenesis remains unclear. The present bioinformatics study indicated that 6 of 10 EXOSC genes, particularly the EXO.index, were able to predict the survival of patients with mantle cell lymphoma (MCL), by analyzing gene expression profiles of 123 patients with MCL from the Gene Expression Omnibus database. The results suggested that EXOSC gene expression may be a molecular marker for MCL. Compared with the whole transcript profile, patients with MCL with a high EXO.index exhibited poorer survival and decreased RNA levels, which was also verified in a second dataset. The EXOSC genes may be associated with DNA repair and B-cell activation pathways, which may be the cause of poorer survival of patients with MCL. © 2019 Spandidos Publications. All rights reserved.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2017]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2.5 最新[2023版] 2.4 最新五年平均 1.664 出版当年[2017版] 1.654 出版当年五年平均 1.39 出版前一年[2016版] 1.871 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191

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通讯作者：

通讯机构： [1]Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191 [2]Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853 [*1]Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, 49 North Garden Road, Haidian, Beijing 100191, P.R. China [*2]Department of General Surgery, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, P.R. China

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