The objective of this study was to establish an ovine model for CH-VAD (CH Biomedical Inc., JiangSu, China) implantable ventricular assist device (IVAD) to evaluate experimental protocols, including anesthesia management, surgical process, autopsy criteria and a validated anticoagulation procedure. Method: IVAD was implanted into the chest of sheep without stopping the beating heart through a left thoracotomy, and the inflow cannula was connected to the left ventricular apex and the outflow cannula was anastomosed to the descending aorta. Results: Totally 23 cases were established: 6 died of an anaesthetic or surgical reasons, one died of lung infection, the other 16 cases survived for more than 15 days, among which four cases were terminated because of decrease of pump flow and the other 12 cases survived for more than 30 days. Conclusions: Sheep models suitable for implantation of CH-VAD implantable LVAD were successfully established and the appropriate safety evaluation indicators of this model were validated in the course of the animal experiments, and the survival rate of the experiments were improved gradually over time. © 2019 World Scientific Publishing Company.