机构：[1]Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China医技科室职能科室临床流行病与循证医学中心心脏彩超首都医科大学附属北京儿童医院[2]Division of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室心脏内科中心首都医科大学附属安贞医院[3]Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA[4]Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA
Studies on the usefulness of speckle tracking echocardiography (STE) in the evaluation of the left ventricle in rats with stress cardiomyopathy (SCM) are limited. Our aim was to investigate whether strain values by STE and cardiac troponin I (cTnI) could predict early myocardial injury in rats with SCM.
SCM was induced in Sprague-Dawley female rats using immobilization (IMO) stress. Biomarkers and echocardiographic parameters were evaluated and compared among groups (group 1 - 30 minutes after IMO stress, group 2 - 24 hours after IMO stress, and control group). We defined myocardial injury as a left ventricular ejection fraction <50%. Possible predictors of early myocardial injury were determined by univariate logistic regression, and independent predictors of early myocardial injury were investigated with multivariable logistic regression.
A total of 44 rats with a mean weight of 426±33 g were evaluated. Group 1 had the highest plasma epinephrine and norepinephrine levels (p<0.001) and the highest heart rate (p<0.001). In univariate logistic regression, cTnI (OR=2.61 [1.02‒10.25], p=0.043) and global longitudinal strain (GLS) (OR=2.13 [1.12‒6.26], p=0.022) were predictive of early myocardial injury. When GLS and cTnI were included in a multivariate analysis, only GLS remained an independent predictor of early myocardial injury (OR=2.67 [1.14‒14.76], p=0.027).
STE is useful for the quantitative detection of subtle myocardial abnormalities in rats with SCM. GLS may provide a reliable and non-invasive method to predict early myocardial injury.
基金：
This research was supported by
the National Natural Science Foundation of China Youth
Science Foundation (81201111).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区声学4 区核医学
JCR分区：
出版当年[2017]版：
Q3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2ACOUSTICSQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China[*1]Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Xicheng District Nanlishi Road 56, Beijing China, 100045
推荐引用方式(GB/T 7714)：
Zhang Hongju,Sun Yan,Liu Xiaoran,et al.Speckle tracking echocardiography in early detection of myocardial injury in a rat model with stress cardiomyopathy.[J].MEDICAL ULTRASONOGRAPHY.2019,21(4):441-448.doi:10.11152/mu-1988.
APA：
Zhang Hongju,Sun Yan,Liu Xiaoran,Yang Ya,Sun Tao...&Ma Ning.(2019).Speckle tracking echocardiography in early detection of myocardial injury in a rat model with stress cardiomyopathy..MEDICAL ULTRASONOGRAPHY,21,(4)
MLA：
Zhang Hongju,et al."Speckle tracking echocardiography in early detection of myocardial injury in a rat model with stress cardiomyopathy.".MEDICAL ULTRASONOGRAPHY 21..4(2019):441-448
