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Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice.

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收录情况： ◇ SCIE

作者：
Ma Lina[1,2] * ; Wang Rong[2] ; Wang Hongjuan[3] ; Zhang Yaxin[1] ; Zhao Zhiwei[2] ;
机构： [1]Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China. [2]Central Laboratory, Xuanwu Hospital Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [3]Department of Biochemistry and Molecular Biology, Yanjing Medical College, Capital Medical University, Beijing, China.
出处：
DOI： 10.29219/fnr.v64.3668
ISSN：

关键词： caloric restriction signaling pathway SIRT1 AMPK mTOR

摘要：
Caloric restriction (CR) can help in improving heart function. There is as yet no consensus on the mechanism of the effect of CR. Silent mating-type information regulation 1 (SIRT1), adenosine monophosphate-activated protein kinase (AMPK), and mTOR are key players in metabolic stress management. We aimed to explore the effect of CR on the myocardial SIRT1/AMPK/mTOR pathway in mice. Thirty-six 6-week-old male C57BL/6J mice were randomly divided into three groups: normal control group (NC group, n = 12), high-energy group (HE group, n = 12) and CR group (n = 12) according to different diets. After 11 months, western blot was used to examine proteins such as p-AMPK, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), SIRT1, and p-mTOR, whereas real-time PCR was used to examine the expression of AMPK, PGC-1α, and SIRT1 transcripts. Compared to the HE group, the CR group displayed increased expression of myocardial p-AMPK protein, SIRT1 protein and mRNA, and PGC-1a mRNA. However, no difference was observed in the expression of p-mTOR protein and mTOR mRNA in the myocardium among the three groups. CR improves the SIRT1/AMPK/PGC-1α pathway in mice myocardium with no effect on the mTOR pathway. © 2020 Lina Ma et al.

基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7202059, 7174310]; Beijing Municipal Administration of Hospitals Incubating Program [PX2020036]; Nation Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600927]
语种：
外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 农林科学
小类 | 3 区 食品科技 4 区 营养学
最新[2023]版：
大类 | 4 区 医学
小类 | 3 区 食品科技 4 区 营养学
JCR分区：
出版当年[2018]版：
Q2 FOOD SCIENCE & TECHNOLOGY Q3 NUTRITION & DIETETICS
最新[2023]版：
Q2 FOOD SCIENCE & TECHNOLOGY Q2 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China. [2]Central Laboratory, Xuanwu Hospital Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Lina,Wang Rong,Wang Hongjuan,et al.Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice.[J].FOOD & NUTRITION RESEARCH.2020,64:-.doi:10.29219/fnr.v64.3668.
APA：
Ma Lina,Wang Rong,Wang Hongjuan,Zhang Yaxin&Zhao Zhiwei.(2020).Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice..FOOD & NUTRITION RESEARCH,64,
MLA：
Ma Lina,et al."Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice.".FOOD & NUTRITION RESEARCH 64.(2020):-

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