机构：[1]Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China[2]Department of Emergency, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China临床科室急诊科首都医科大学附属北京儿童医院[3]Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China
Background: Children with vitamin A, D, and E deficiency are susceptible to respiratory infections. However, the correlations between the levels with Mycoplasma pneumoniae pneumonia (MPP) and patient MPP occurrence is still unclear. This study aims to measure and compare the serum levels in severe (sMPP) and non-severe MPP (nsM PP) and to investigate the correlations between their levels and the occurrence of MPP. Methods: A total of 122 children were enrolled, including 52 sMPP and 70 nsMPP aged 0-15 years old in 2015-2018. The serum levels of vitamins A, D, and E were measured and compared, and two-category logistic regression was used for correlation analysis of vitamins A, D, and E levels with nsMPP and sMPP. Results: The age was older (7.12 vs. 4.01 y, P=0.002) in the sMPP samples than that in the nsMPP samples. Vitamin A deficiency was present in both the nsMPP and sMPP samples; its level was significantly lower (0.15 +/- 0.06 vs. 0.19 +/- 0.07, P=0.0193) in the sMPP serum than that in the nsMPP serum. Vitamins E and D in the sMPP samples were significantly lower (vitamin E 7.43 +/- 1.55 vs. 8.22 +/- 2.22, P=0.0104; vitamin D 23.08 +/- 11.0 vs. 32.07 +/- 19.2, P=0.0007) than that in the nsMPP group; both sMPP and nsMPP did not show a deficiency of vitamins E and D. Logistic regression analysis revealed that vitamin A deficiency was significantly (OR 0.001, 95% CI: 0.001-0.334, P=0.009) associated with sMPP, and vitamin A supplementation could reduce the incidence of sMPP. In y sMPP, the incidence of vitamin A deficiency was 62.5%, while >= 6 y, 85%, showing a significant difference. Vitamin A level in <6 y sMPP was significantly lower than that in >= 6 y sMPP. Conclusions: Vitamin A deficiency is associated with sMPP and more likely present in the younger sMPP samples. Therefore, it is important to watch and supplement vitamin A in M. pneumoniae infection patients.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7163232, S170003, S160004]; Young Scientists Fund of Peking University Third Hospital [BYSY2016016]; Medical and Health Science and Technology Development Research Center of National Health and Family Planning Commission [W2015EAE016]
第一作者机构：[1]Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China
通讯作者：
通讯机构：[1]Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China[*1]Department of Pediatrics, Peking University Third Hospital, No. 49, Hua Yuan Bei Lu, Haidian District, Beijing 100191, China.
推荐引用方式(GB/T 7714)：
Yan Xing,Kai Sheng,Xiumei Xiao,et al.Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children[J].ANNALS OF TRANSLATIONAL MEDICINE.2020,8(4):-.doi:10.21037/atm.2020.02.33.
APA：
Yan Xing,Kai Sheng,Xiumei Xiao,Jiawei Li,Hongling Wei...&Xiaomei Tong.(2020).Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children.ANNALS OF TRANSLATIONAL MEDICINE,8,(4)
MLA：
Yan Xing,et al."Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children".ANNALS OF TRANSLATIONAL MEDICINE 8..4(2020):-
