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Mitochondria determine the sequential propagation of the calcium macrodomains revealed by the super-resolution calcium lantern imaging

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收录情况： ◇ SCIE ◇ CSCD-C

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机构： [1]State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing 100871, China [2]PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China [3]Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [4]Institute for Brain Research and Rehabilitation (IBRR), Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 200062, China

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关键词： super-resolution imaging ER Ca2+ release mitochondrial sequential response

摘要：

Despite the wide application of super-resolution (SR) microscopy in biological studies of cells, the technology is rarely used to monitor functional changes in live cells. By combining fast spinning disc-confocal structured illumination microscopy (SD-SIM) with loading of cytosolic fluorescent Ca2+ indicators, we have developed an SR method for visualization of regional Ca2+ dynamics and related cellular organelle morphology and dynamics, termed SR calcium lantern imaging. In COS-7 cells stimulated with ATP, we have identified various calcium macrodomains characterized by different types of Ca-2+ release from endoplasmic reticulum (ER) stores. Finally, we demonstrated various roles of mitochondria in mediating calcium signals from different sources; while mitochondria can globally potentiate the Ca-2+ entry associated with store release, mitochondria also locally control Ca2+ release from the neighboring ER stores and assist in their refilling processes.

基金：

基金编号： 2016YFA0500400 81925022 91854112 31327901 31521062 31570839 91750203 L172003 7182063

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出版当年[2019]版：

大类 | 1 区

生物

小类 | 1 区生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 2 区生物学

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出版当年[2018]版：

Q1 BIOLOGY

最新[2023]版：

Q1 BIOLOGY

影响因子： 8 最新[2023版] 7.3 最新五年平均 3.583 出版当年[2018版] 2.846 出版当年五年平均 3.085 出版前一年[2017版] 4.611 出版后一年[2019版]

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第一作者机构： [1]State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing 100871, China

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