Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease
机构：[1]Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, China[2]Shenzhen Key Laboratory of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Chinese Academy of Science (CAS) Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China深圳市康宁医院深圳医学信息中心[3]Laboratory Animal Center, Southeast University, Nanjing 210009, China[4]Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing 100053, China神经科系统神经内科首都医科大学宣武医院[5]Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA[6]University of the Chinese Academy of Sciences, Beijing 100049, China[7]Beijing Institute of Geriatrics, Beijing, China[8]National Clinical Research Center for Geriatric Disorders, Beijing, China[9]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
The parahippocampal gyrus-orbitofrontal cortex (PHG-OFC) circuit in humans is homologous to the postrhinal cortex (POR)-ventral lateral orbitofrontal cortex (vlOFC) circuit in rodents. Both are associated with visuospatial malfunctions in Alzheimer's disease (AD). However, the underlying mechanisms remain to be elucidated. In this study, we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice, and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging (MRI) in patients on the AD spectrum. We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice. Moreover, MRI measurements of the PHG-OFC circuit had an accuracy of 77.33% for the classification of amnestic mild cognitive impairment converters versus non-converters. Thus, the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD, thereby providing a potential predictor for AD progression and a promising interventional approach for AD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81420108012, 81671046, 91832000, 31700936]; Program of Excellent Talents in Medical Science of Jiangsu Province, China [JCRCA2016006]; Special Project of Clinical Medicine Science and Technology in Jiangsu Province, China [BL2014077]; Special Project of Clinical Medicine Science and Technology in Guangdong Province [2017A030310496]; Key-Area Research and Development Program of Guangdong Province, China [2018B030331001]; National Special Support Grant [W02020453]; Guangdong Provincial Key Laboratory of Brain Connectome and Behavior [2017B030301017]
第一作者机构：[1]Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, China
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推荐引用方式(GB/T 7714)：
Zhu Lin,Wang Zan,Du Zhanhong,et al.Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease[J].NEUROSCIENCE BULLETIN.2020,36(8):831-844.doi:10.1007/s12264-020-00498-3.
APA：
Zhu, Lin,Wang, Zan,Du, Zhanhong,Qi, Xinyang,Shu, Hao...&Zhang, Zhijun.(2020).Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease.NEUROSCIENCE BULLETIN,36,(8)
MLA：
Zhu, Lin,et al."Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease".NEUROSCIENCE BULLETIN 36..8(2020):831-844
