机构：[1]Xuan Wu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China首都医科大学宣武医院[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, Guangdong Province 510405, PR China深圳市中医院深圳医学信息中心[3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[4]China National Clinical Research Center for Neurological Diseases, China首都医科大学附属天坛医院[5]National Center for Safety Evaluation of Drugs, National Institute for Food and Drug Control, Beijing 100176, PR China
The effect of cornel iridoid glycoside (CIG), main component extracted from Corms officinalis, on microglia activation has not been elucidated so far. We induced a mouse model of multiple sclerosis (MS), namely, the experimental autoimmune encephalomyelitis (EAE) model by immunization subcutaneously with the MOG(35-55) peptide, which causes neuroinflammation and microglia activation. Our data demonstrated that CIG delayed the onset of the EAE, ameliorated the severity of the symptoms and inhibited the activation of microglia in different brain regions. In addition, we also found that CIG has therapeutic potential by modulating microglia polarization by reducing the expression and release of proinflammatory cytokines, chemokines and inhibiting phosphorylation in the JAK/STAT cell signalling pathway. Based on our findings, CIG might be a promising candidate for the prevention of neurological disorders such as multiple sclerosis (MS).
基金：
Beijing Natural Science Foundation
(7162208), Beijing Health and Technical Personal of High-level Plan
(No. 2014-3-052), National Natural Science Foundation of China (No.
81473740, No. 81673627), Guangzhou Science Technology and
Innovation Commission Technology Research Projects
(201805010005), Beijing Municipal Administration of Hospitals
Incubating Program (PZ2016027) and Youth Programme of Beijing
Municipal Administration of Hospitals' (QML20160805).
第一作者机构：[1]Xuan Wu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, Guangdong Province 510405, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Xuan Wu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, Guangdong Province 510405, PR China[3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[4]China National Clinical Research Center for Neurological Diseases, China[5]National Center for Safety Evaluation of Drugs, National Institute for Food and Drug Control, Beijing 100176, PR China[*1]Xuan Wu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
推荐引用方式(GB/T 7714)：
Qu Zhao,Zheng Na,Wei Yuzhen,et al.Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway[J].JOURNAL OF NEUROIMMUNOLOGY.2019,330:96-107.doi:10.1016/j.jneuroim.2019.01.014.
APA：
Qu, Zhao,Zheng, Na,Wei, Yuzhen,Chen, Yujing,Zhang, Yifan...&Yin, Linlin.(2019).Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway.JOURNAL OF NEUROIMMUNOLOGY,330,
MLA：
Qu, Zhao,et al."Effect of cornel iridoid glycoside on microglia activation through suppression of the JAK/STAT signalling pathway".JOURNAL OF NEUROIMMUNOLOGY 330.(2019):96-107
